Canada-Denmark MRI scoring system of the spine in patients with axial spondyloarthritis: Updated definitions, scoring rules and inter-reader reliability in a multiple reader setting

Simon Krabbe; Mikkel Østergaard; Susanne J. Pedersen; Ulrich Weber; Georg Kröber; Walter Makysmowych; Robert G.W. Lambert

doi:10.1136/rmdopen-2019-001057

Canada-Denmark MRI scoring system of the spine in patients with axial spondyloarthritis: Updated definitions, scoring rules and inter-reader reliability in a multiple reader setting

Simon Krabbe^*, Mikkel Østergaard, Susanne J. Pedersen, Ulrich Weber, Georg Kröber, Walter Makysmowych, Robert G.W. Lambert

^*Corresponding author af dette arbejde

4 Citationer (Scopus)

Abstract

Objective To validate the Canada-Denmark (CANDEN) MRI scoring system for the spine in axial spondyloarthritis with updated lesion definitions. Methods Lesion definitions in the CANDEN system were updated and illustrated by a consensus set of reference images. Sagittal spine MRIs of 40 patients with axial spondyloarthritis obtained at baseline and at week 52 after initiation of treatment with the tumour necrosis factor inhibitor golimumab were evaluated in unknown chronology by seven readers blinded to all other data. Results CANDEN MRI spine inflammation score had very good reliability for status scores (single-measure intraclass correlation coefficient (ICC) of 21 reader pairs median of 0.91 (IQR 0.88-0.92)) and change scores (ICC 0.88 (0.86-0.92)). CANDEN MRI spine fat score had good to very good reliability for status scores (ICC 0.79 (0.75-0.86)) and moderate to good reliability for detecting change (ICC 0.59 (0.46-0.73)). CANDEN MRI spine bone erosion score and CANDEN MRI spine new bone formation score had slight to moderate reliability for status scores (ICC 0.38 (0.32-0.52) and 0.39 (0.27-0.49), respectively). Conclusion The CANDEN MRI spine scoring system allows a comprehensive evaluation of inflammation, fat, bone erosion and new bone formation of the spine in patients with axial spondyloarthritis. It demonstrated very good reliability for detecting change in inflammation, moderate to good reliability for detecting change in fat, and slight to moderate reliability for detecting bone erosions and new bone formation. Studies with longer follow-up or patients with more advanced spinal involvement may be needed to reliably detect change in bone erosion and new bone formation scores.

Originalsprog	Engelsk
Artikelnummer	e001057
Tidsskrift	RMD Open
Vol/bind	5
Udgave nummer	2
Antal sider	10
ISSN	2056-5933
DOI	https://doi.org/10.1136/rmdopen-2019-001057
Status	Udgivet - 2019

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10.1136/rmdopen-2019-001057Licens: CC BY-NC

e001057.fullForlagets udgivne version, 1,14 MBLicens: CC BY-NC

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Canada-Denmark MRI scoring system of the spine in patients with axial spondyloarthritis : Updated definitions, scoring rules and inter-reader reliability in a multiple reader setting. / Krabbe, Simon; Østergaard, Mikkel; Pedersen, Susanne J. et al.

I: RMD Open, Bind 5, Nr. 2, e001057, 2019.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{30274e876b634121b1279e631b50993d,

title = "Canada-Denmark MRI scoring system of the spine in patients with axial spondyloarthritis: Updated definitions, scoring rules and inter-reader reliability in a multiple reader setting",

abstract = "Objective To validate the Canada-Denmark (CANDEN) MRI scoring system for the spine in axial spondyloarthritis with updated lesion definitions. Methods Lesion definitions in the CANDEN system were updated and illustrated by a consensus set of reference images. Sagittal spine MRIs of 40 patients with axial spondyloarthritis obtained at baseline and at week 52 after initiation of treatment with the tumour necrosis factor inhibitor golimumab were evaluated in unknown chronology by seven readers blinded to all other data. Results CANDEN MRI spine inflammation score had very good reliability for status scores (single-measure intraclass correlation coefficient (ICC) of 21 reader pairs median of 0.91 (IQR 0.88-0.92)) and change scores (ICC 0.88 (0.86-0.92)). CANDEN MRI spine fat score had good to very good reliability for status scores (ICC 0.79 (0.75-0.86)) and moderate to good reliability for detecting change (ICC 0.59 (0.46-0.73)). CANDEN MRI spine bone erosion score and CANDEN MRI spine new bone formation score had slight to moderate reliability for status scores (ICC 0.38 (0.32-0.52) and 0.39 (0.27-0.49), respectively). Conclusion The CANDEN MRI spine scoring system allows a comprehensive evaluation of inflammation, fat, bone erosion and new bone formation of the spine in patients with axial spondyloarthritis. It demonstrated very good reliability for detecting change in inflammation, moderate to good reliability for detecting change in fat, and slight to moderate reliability for detecting bone erosions and new bone formation. Studies with longer follow-up or patients with more advanced spinal involvement may be needed to reliably detect change in bone erosion and new bone formation scores.",

keywords = "magnetic resonance imaging, outcomes research, spondyloarthritis",

author = "Simon Krabbe and Mikkel {\O}stergaard and Pedersen, {Susanne J.} and Ulrich Weber and Georg Kr{\"o}ber and Walter Makysmowych and Lambert, {Robert G.W.}",

year = "2019",

doi = "10.1136/rmdopen-2019-001057",

language = "English",

volume = "5",

journal = "RMD Open",

issn = "2056-5933",

publisher = "BMJ Publishing Group",

number = "2",

}

TY - JOUR

T1 - Canada-Denmark MRI scoring system of the spine in patients with axial spondyloarthritis

T2 - Updated definitions, scoring rules and inter-reader reliability in a multiple reader setting

AU - Krabbe, Simon

AU - Østergaard, Mikkel

AU - Pedersen, Susanne J.

AU - Weber, Ulrich

AU - Kröber, Georg

AU - Makysmowych, Walter

AU - Lambert, Robert G.W.

PY - 2019

Y1 - 2019

N2 - Objective To validate the Canada-Denmark (CANDEN) MRI scoring system for the spine in axial spondyloarthritis with updated lesion definitions. Methods Lesion definitions in the CANDEN system were updated and illustrated by a consensus set of reference images. Sagittal spine MRIs of 40 patients with axial spondyloarthritis obtained at baseline and at week 52 after initiation of treatment with the tumour necrosis factor inhibitor golimumab were evaluated in unknown chronology by seven readers blinded to all other data. Results CANDEN MRI spine inflammation score had very good reliability for status scores (single-measure intraclass correlation coefficient (ICC) of 21 reader pairs median of 0.91 (IQR 0.88-0.92)) and change scores (ICC 0.88 (0.86-0.92)). CANDEN MRI spine fat score had good to very good reliability for status scores (ICC 0.79 (0.75-0.86)) and moderate to good reliability for detecting change (ICC 0.59 (0.46-0.73)). CANDEN MRI spine bone erosion score and CANDEN MRI spine new bone formation score had slight to moderate reliability for status scores (ICC 0.38 (0.32-0.52) and 0.39 (0.27-0.49), respectively). Conclusion The CANDEN MRI spine scoring system allows a comprehensive evaluation of inflammation, fat, bone erosion and new bone formation of the spine in patients with axial spondyloarthritis. It demonstrated very good reliability for detecting change in inflammation, moderate to good reliability for detecting change in fat, and slight to moderate reliability for detecting bone erosions and new bone formation. Studies with longer follow-up or patients with more advanced spinal involvement may be needed to reliably detect change in bone erosion and new bone formation scores.

AB - Objective To validate the Canada-Denmark (CANDEN) MRI scoring system for the spine in axial spondyloarthritis with updated lesion definitions. Methods Lesion definitions in the CANDEN system were updated and illustrated by a consensus set of reference images. Sagittal spine MRIs of 40 patients with axial spondyloarthritis obtained at baseline and at week 52 after initiation of treatment with the tumour necrosis factor inhibitor golimumab were evaluated in unknown chronology by seven readers blinded to all other data. Results CANDEN MRI spine inflammation score had very good reliability for status scores (single-measure intraclass correlation coefficient (ICC) of 21 reader pairs median of 0.91 (IQR 0.88-0.92)) and change scores (ICC 0.88 (0.86-0.92)). CANDEN MRI spine fat score had good to very good reliability for status scores (ICC 0.79 (0.75-0.86)) and moderate to good reliability for detecting change (ICC 0.59 (0.46-0.73)). CANDEN MRI spine bone erosion score and CANDEN MRI spine new bone formation score had slight to moderate reliability for status scores (ICC 0.38 (0.32-0.52) and 0.39 (0.27-0.49), respectively). Conclusion The CANDEN MRI spine scoring system allows a comprehensive evaluation of inflammation, fat, bone erosion and new bone formation of the spine in patients with axial spondyloarthritis. It demonstrated very good reliability for detecting change in inflammation, moderate to good reliability for detecting change in fat, and slight to moderate reliability for detecting bone erosions and new bone formation. Studies with longer follow-up or patients with more advanced spinal involvement may be needed to reliably detect change in bone erosion and new bone formation scores.

KW - magnetic resonance imaging

KW - outcomes research

KW - spondyloarthritis

U2 - 10.1136/rmdopen-2019-001057

DO - 10.1136/rmdopen-2019-001057

M3 - Journal article

C2 - 31673422

AN - SCOPUS:85073594119

SN - 2056-5933

VL - 5

JO - RMD Open

JF - RMD Open

IS - 2

M1 - e001057

ER -

Canada-Denmark MRI scoring system of the spine in patients with axial spondyloarthritis: Updated definitions, scoring rules and inter-reader reliability in a multiple reader setting

Abstract

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