Calcium-Sensing Receptor (CaSR)

J. Tfelt-Hansen; E. M. Brown

doi:10.1016/b978-0-12-378630-2.00140-7

Calcium-Sensing Receptor (CaSR)

^*Corresponding author af dette arbejde

Abstract

The calcium-sensing receptor (CaSR) is a membrane-bound, G-protein-coupled receptor that is expressed in all tissues that regulate extracellular calcium homeostasis - the parathyroid glands, thyroidal C cells, bone, kidney, and intestine. The CaSR senses the level of calcium in the blood and acts, therefore, as the body's thermostat for calcium (or calciostat). When the level of calcium changes by even a few percent from its normal level, the CaSR senses this change and then modulates the functions of the cells expressing it so as to restore the level of blood calcium to normal. The CaSR-mediated regulation of the secretion of parathyroid hormone plays a particularly important role in calcium homeostasis, because it directly or indirectly modulates the functions of all tissues involved in regulating blood calcium.

Originalsprog	Engelsk
Titel	Encyclopedia of Biological Chemistry : Second Edition
Antal sider	5
Forlag	Elsevier Science Inc.
Publikationsdato	15 feb. 2013
Sider	326-330
ISBN (Trykt)	9780123786302
ISBN (Elektronisk)	9780123786319
DOI	https://doi.org/10.1016/b978-0-12-378630-2.00140-7
Status	Udgivet - 15 feb. 2013
Udgivet eksternt	Ja

Adgang til dokumentet

10.1016/b978-0-12-378630-2.00140-7

Andre filer og links

Link to publication in Scopus

Citationsformater

@inbook{45366e5f8c4542fe8120b1c8b2fca5d6,

title = "Calcium-Sensing Receptor (CaSR)",

abstract = "The calcium-sensing receptor (CaSR) is a membrane-bound, G-protein-coupled receptor that is expressed in all tissues that regulate extracellular calcium homeostasis - the parathyroid glands, thyroidal C cells, bone, kidney, and intestine. The CaSR senses the level of calcium in the blood and acts, therefore, as the body's thermostat for calcium (or calciostat). When the level of calcium changes by even a few percent from its normal level, the CaSR senses this change and then modulates the functions of the cells expressing it so as to restore the level of blood calcium to normal. The CaSR-mediated regulation of the secretion of parathyroid hormone plays a particularly important role in calcium homeostasis, because it directly or indirectly modulates the functions of all tissues involved in regulating blood calcium.",

keywords = "1,25(OH)O, Bone, Calcium, Calcium-sensing receptor, CaSR, G protein, G-protein-coupled receptor, Intestine, Kidney, Parathyroid gland, Parathyroid hormone, Protein kinase, Second messenger",

author = "J. Tfelt-Hansen and Brown, {E. M.}",

year = "2013",

month = feb,

day = "15",

doi = "10.1016/b978-0-12-378630-2.00140-7",

language = "English",

isbn = "9780123786302",

pages = "326--330",

booktitle = "Encyclopedia of Biological Chemistry",

publisher = "Elsevier Science Inc.",

address = "United States",

}

TY - CHAP

T1 - Calcium-Sensing Receptor (CaSR)

AU - Tfelt-Hansen, J.

AU - Brown, E. M.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - The calcium-sensing receptor (CaSR) is a membrane-bound, G-protein-coupled receptor that is expressed in all tissues that regulate extracellular calcium homeostasis - the parathyroid glands, thyroidal C cells, bone, kidney, and intestine. The CaSR senses the level of calcium in the blood and acts, therefore, as the body's thermostat for calcium (or calciostat). When the level of calcium changes by even a few percent from its normal level, the CaSR senses this change and then modulates the functions of the cells expressing it so as to restore the level of blood calcium to normal. The CaSR-mediated regulation of the secretion of parathyroid hormone plays a particularly important role in calcium homeostasis, because it directly or indirectly modulates the functions of all tissues involved in regulating blood calcium.

AB - The calcium-sensing receptor (CaSR) is a membrane-bound, G-protein-coupled receptor that is expressed in all tissues that regulate extracellular calcium homeostasis - the parathyroid glands, thyroidal C cells, bone, kidney, and intestine. The CaSR senses the level of calcium in the blood and acts, therefore, as the body's thermostat for calcium (or calciostat). When the level of calcium changes by even a few percent from its normal level, the CaSR senses this change and then modulates the functions of the cells expressing it so as to restore the level of blood calcium to normal. The CaSR-mediated regulation of the secretion of parathyroid hormone plays a particularly important role in calcium homeostasis, because it directly or indirectly modulates the functions of all tissues involved in regulating blood calcium.

KW - 1,25(OH)O

KW - Bone

KW - Calcium

KW - Calcium-sensing receptor

KW - CaSR

KW - G protein

KW - G-protein-coupled receptor

KW - Intestine

KW - Kidney

KW - Parathyroid gland

KW - Parathyroid hormone

KW - Protein kinase

KW - Second messenger

UR - http://www.scopus.com/inward/record.url?scp=85042749851&partnerID=8YFLogxK

U2 - 10.1016/b978-0-12-378630-2.00140-7

DO - 10.1016/b978-0-12-378630-2.00140-7

M3 - Book chapter

AN - SCOPUS:85042749851

SN - 9780123786302

SP - 326

EP - 330

BT - Encyclopedia of Biological Chemistry

PB - Elsevier Science Inc.

ER -

Calcium-Sensing Receptor (CaSR)

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater