Calcitonin gene-related peptide and adrenomedullin release in humans: effects of exercise and hypoxia

Philip Hasbak; Carsten Lundby; Niels Vidiendal Olsen; Søren Schifter; Inge-Lis Kanstrup

Calcitonin gene-related peptide and adrenomedullin release in humans: effects of exercise and hypoxia

Philip Hasbak, Carsten Lundby, Niels Vidiendal Olsen, Søren Schifter, Inge-Lis Kanstrup

Eyepath Lab

20 Citationer (Scopus)

Abstract

Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are potent vasorelaxant peptides. This study examined exercise-induced changes in CGRP and AM levels in 12 healthy sea level natives at sea level (SL) and subsequently after 24 h (HA1) and 5 days (HA5) in high altitude hypoxia (4559 m). Plasma values of CGRP, AM, calcitonin, noradrenaline, adrenaline, lactate and heart rate were measured at rest and during maximal exercise (W(max)). On each study day, the dopamine D(2)-receptor antagonist, domperidone (30 mg; n=6), or no medication (n=6) was given 1 h before exercise. W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. The maximal CGRP levels at W(max) were significantly decreased at HA1 (74.3+/-6.1 pmol/l; p=0.002) and HA5 (69.6+/-6.0 pmol/l; p

Originalsprog	Engelsk
Tidsskrift	Regulatory Peptides
Vol/bind	108
Udgave nummer	2-3
Sider (fra-til)	89-95
Antal sider	7
ISSN	0167-0115
Status	Udgivet - 15 okt. 2002

Citationsformater

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title = "Calcitonin gene-related peptide and adrenomedullin release in humans: effects of exercise and hypoxia",

abstract = "Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are potent vasorelaxant peptides. This study examined exercise-induced changes in CGRP and AM levels in 12 healthy sea level natives at sea level (SL) and subsequently after 24 h (HA1) and 5 days (HA5) in high altitude hypoxia (4559 m). Plasma values of CGRP, AM, calcitonin, noradrenaline, adrenaline, lactate and heart rate were measured at rest and during maximal exercise (W(max)). On each study day, the dopamine D(2)-receptor antagonist, domperidone (30 mg; n=6), or no medication (n=6) was given 1 h before exercise. W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. The maximal CGRP levels at W(max) were significantly decreased at HA1 (74.3+/-6.1 pmol/l; p=0.002) and HA5 (69.6+/-6.0 pmol/l; p",

keywords = "Adrenomedullin, Adult, Altitude, Altitude Sickness, Calcitonin, Calcitonin Gene-Related Peptide, Domperidone, Dopamine Antagonists, Epinephrine, Exercise, Female, Heart Rate, Humans, Lactates, Male, Norepinephrine, Peptides, Reference Values, Vasodilation",

author = "Philip Hasbak and Carsten Lundby and Olsen, {Niels Vidiendal} and S{\o}ren Schifter and Inge-Lis Kanstrup",

year = "2002",

month = oct,

day = "15",

language = "English",

volume = "108",

pages = "89--95",

journal = "Regulatory Peptides",

issn = "0167-0115",

publisher = "Elsevier",

number = "2-3",

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TY - JOUR

T1 - Calcitonin gene-related peptide and adrenomedullin release in humans

T2 - effects of exercise and hypoxia

AU - Hasbak, Philip

AU - Lundby, Carsten

AU - Olsen, Niels Vidiendal

AU - Schifter, Søren

AU - Kanstrup, Inge-Lis

PY - 2002/10/15

Y1 - 2002/10/15

N2 - Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are potent vasorelaxant peptides. This study examined exercise-induced changes in CGRP and AM levels in 12 healthy sea level natives at sea level (SL) and subsequently after 24 h (HA1) and 5 days (HA5) in high altitude hypoxia (4559 m). Plasma values of CGRP, AM, calcitonin, noradrenaline, adrenaline, lactate and heart rate were measured at rest and during maximal exercise (W(max)). On each study day, the dopamine D(2)-receptor antagonist, domperidone (30 mg; n=6), or no medication (n=6) was given 1 h before exercise. W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. The maximal CGRP levels at W(max) were significantly decreased at HA1 (74.3+/-6.1 pmol/l; p=0.002) and HA5 (69.6+/-6.0 pmol/l; p

AB - Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are potent vasorelaxant peptides. This study examined exercise-induced changes in CGRP and AM levels in 12 healthy sea level natives at sea level (SL) and subsequently after 24 h (HA1) and 5 days (HA5) in high altitude hypoxia (4559 m). Plasma values of CGRP, AM, calcitonin, noradrenaline, adrenaline, lactate and heart rate were measured at rest and during maximal exercise (W(max)). On each study day, the dopamine D(2)-receptor antagonist, domperidone (30 mg; n=6), or no medication (n=6) was given 1 h before exercise. W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. The maximal CGRP levels at W(max) were significantly decreased at HA1 (74.3+/-6.1 pmol/l; p=0.002) and HA5 (69.6+/-6.0 pmol/l; p

KW - Adrenomedullin

KW - Adult

KW - Altitude

KW - Altitude Sickness

KW - Calcitonin

KW - Calcitonin Gene-Related Peptide

KW - Domperidone

KW - Dopamine Antagonists

KW - Epinephrine

KW - Exercise

KW - Female

KW - Heart Rate

KW - Humans

KW - Lactates

KW - Male

KW - Norepinephrine

KW - Peptides

KW - Reference Values

KW - Vasodilation

M3 - Journal article

C2 - 12220731

SN - 0167-0115

VL - 108

SP - 89

EP - 95

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 2-3

ER -

Calcitonin gene-related peptide and adrenomedullin release in humans: effects of exercise and hypoxia

Abstract

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