C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation

Jeppe Zacho; Anne Tybjaerg-Hansen; Jan Skov Jensen; Peer Grande; Henrik Sillesen; Børge G Nordestgaard

C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation

Jeppe Zacho, Anne Tybjaerg-Hansen, Jan Skov Jensen, Peer Grande, Henrik Sillesen, Børge G Nordestgaard

Abstract

Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease.
Udgivelsesdato: 2009-May

Bidragets oversatte titel	C-reactive protein and risk of ischaemic vascular and cerebrovascular disease--secondary publication
Originalsprog	Dansk
Tidsskrift	Ugeskrift for læger
Vol/bind	171
Udgave nummer	21
Sider (fra-til)	1751-5
Antal sider	5
ISSN	0041-5782
Status	Udgivet - 2009

Citationsformater

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title = "C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation",

abstract = "Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease. Udgivelsesdato: 2009-May",

author = "Jeppe Zacho and Anne Tybjaerg-Hansen and Jensen, {Jan Skov} and Peer Grande and Henrik Sillesen and Nordestgaard, {B{\o}rge G}",

note = "Keywords: Atherosclerosis; Biological Markers; C-Reactive Protein; Cerebrovascular Disorders; Cohort Studies; Genetic Predisposition to Disease; Genotype; Humans; Myocardial Ischemia; Polymorphism, Genetic; Risk Factors",

year = "2009",

language = "Dansk",

volume = "171",

pages = "1751--5",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - C-reaktivt protein og risiko for iskaemisk hjerte- og cerebrovaskulaer sygdom--sekundaerpublikation

AU - Zacho, Jeppe

AU - Tybjaerg-Hansen, Anne

AU - Jensen, Jan Skov

AU - Grande, Peer

AU - Sillesen, Henrik

AU - Nordestgaard, Børge G

N1 - Keywords: Atherosclerosis; Biological Markers; C-Reactive Protein; Cerebrovascular Disorders; Cohort Studies; Genetic Predisposition to Disease; Genotype; Humans; Myocardial Ischemia; Polymorphism, Genetic; Risk Factors

PY - 2009

Y1 - 2009

N2 - Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease. Udgivelsesdato: 2009-May

AB - Elevated levels of C reactive protein (CRP) are associated with increased risk of ischaemic vascular disease. We tested whether this is a causal association. CRP > 3 vs < 1 mg/l were associated with an increased risk of ischaemic heart- and cerebrovascular disease of 1.6 and 1.3, respectively. Four CRP polymorphisms were associated with a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of 32% and 25% for ischemic heart- and ischemic cerebrovascular disease, respectively. However, these genotype combinations were not associated with an increased risk of ischaemic vascular disease. Udgivelsesdato: 2009-May

M3 - Tidsskriftartikel

C2 - 19492468

SN - 0041-5782

VL - 171

SP - 1751

EP - 1755

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 21

ER -