C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

Esther Zimmermann; Rodolphe Anty; Joan Tordjman; An Verrijken; Philippe Gual; Albert Tran; Antonio Iannelli; Jean Gugenheim; Pierre Bedossa; Sven Francque; Yannick Le Marchand-Brustel; Karine Clement; Luc Van Gaal; Thorkild I A Sørensen; Tine Jess

doi:10.1016/j.jhep.2010.12.017

C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

Esther Zimmermann, Rodolphe Anty, Joan Tordjman, An Verrijken, Philippe Gual, Albert Tran, Antonio Iannelli, Jean Gugenheim, Pierre Bedossa, Sven Francque, Yannick Le Marchand-Brustel, Karine Clement, Luc Van Gaal, Thorkild I A Sørensen, Tine Jess

66 Citationer (Scopus)

Abstract

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD and hs-CRP are independent of body mass index (BMI) in its broad range among obese patients. Methods: A total of 627 obese adults (80% females), representing three cohorts from France and Belgium, had information on liver histology obtained from liver biopsies and measures of hs-CRP and BMI. We investigated whether the different features of NAFLD and BMI were associated with hs-CRP, with and without mutual adjustments using linear regression. Results: BMI and hs-CRP were strongly associated. Per every 10% increase in BMI the hs-CRP level increased by 19-20% (p <0.001), and adjustment for NAFLD-stage (including no-NAFLD) did not influence the association. We found no BMI-independent association between NASH and hs-CRP. However, a positive association between degree of steatosis and hs-CRP was observed (p <0.05) and this effect remained significant after adjusting for BMI, lobular inflammation, hepatocyte ballooning, and fibrosis. We found no significant associations between the other features of NAFLD and hs-CRP. Conclusions: This study indicates that it is the accumulation of fat -both in the adipose tissue and in liver steatosis- that leads to increased hs-CRP levels among obese patients. Thus, hs-CRP may be a marker of steatosis, but not of severity of NAFLD, in obese patients.

Originalsprog	Engelsk
Tidsskrift	Journal of Hepatology
Vol/bind	55
Udgave nummer	3
Sider (fra-til)	660-5
Antal sider	6
ISSN	0168-8278
DOI	https://doi.org/10.1016/j.jhep.2010.12.017
Status	Udgivet - sep. 2011

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10.1016/j.jhep.2010.12.017

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Zimmermann, E., Anty, R., Tordjman, J., Verrijken, A., Gual, P., Tran, A., Iannelli, A., Gugenheim, J., Bedossa, P., Francque, S., Le Marchand-Brustel, Y., Clement, K., Van Gaal, L., Sørensen, T. I. A., & Jess, T. (2011). C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients. Journal of Hepatology, 55(3), 660-5. https://doi.org/10.1016/j.jhep.2010.12.017

Zimmermann, E, Anty, R, Tordjman, J, Verrijken, A, Gual, P, Tran, A, Iannelli, A, Gugenheim, J, Bedossa, P, Francque, S, Le Marchand-Brustel, Y, Clement, K, Van Gaal, L, Sørensen, TIA & Jess, T 2011, 'C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients', Journal of Hepatology, bind 55, nr. 3, s. 660-5. https://doi.org/10.1016/j.jhep.2010.12.017

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title = "C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients",

abstract = "Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD and hs-CRP are independent of body mass index (BMI) in its broad range among obese patients. Methods: A total of 627 obese adults (80% females), representing three cohorts from France and Belgium, had information on liver histology obtained from liver biopsies and measures of hs-CRP and BMI. We investigated whether the different features of NAFLD and BMI were associated with hs-CRP, with and without mutual adjustments using linear regression. Results: BMI and hs-CRP were strongly associated. Per every 10% increase in BMI the hs-CRP level increased by 19-20% (p <0.001), and adjustment for NAFLD-stage (including no-NAFLD) did not influence the association. We found no BMI-independent association between NASH and hs-CRP. However, a positive association between degree of steatosis and hs-CRP was observed (p <0.05) and this effect remained significant after adjusting for BMI, lobular inflammation, hepatocyte ballooning, and fibrosis. We found no significant associations between the other features of NAFLD and hs-CRP. Conclusions: This study indicates that it is the accumulation of fat -both in the adipose tissue and in liver steatosis- that leads to increased hs-CRP levels among obese patients. Thus, hs-CRP may be a marker of steatosis, but not of severity of NAFLD, in obese patients.",

author = "Esther Zimmermann and Rodolphe Anty and Joan Tordjman and An Verrijken and Philippe Gual and Albert Tran and Antonio Iannelli and Jean Gugenheim and Pierre Bedossa and Sven Francque and {Le Marchand-Brustel}, Yannick and Karine Clement and {Van Gaal}, Luc and S{\o}rensen, {Thorkild I A} and Tine Jess",

year = "2011",

month = sep,

doi = "10.1016/j.jhep.2010.12.017",

language = "English",

volume = "55",

pages = "660--5",

journal = "Journal of Hepatology, Supplement",

issn = "0169-5185",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

AU - Zimmermann, Esther

AU - Anty, Rodolphe

AU - Tordjman, Joan

AU - Verrijken, An

AU - Gual, Philippe

AU - Tran, Albert

AU - Iannelli, Antonio

AU - Gugenheim, Jean

AU - Bedossa, Pierre

AU - Francque, Sven

AU - Le Marchand-Brustel, Yannick

AU - Clement, Karine

AU - Van Gaal, Luc

AU - Sørensen, Thorkild I A

AU - Jess, Tine

PY - 2011/9

Y1 - 2011/9

N2 - Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD and hs-CRP are independent of body mass index (BMI) in its broad range among obese patients. Methods: A total of 627 obese adults (80% females), representing three cohorts from France and Belgium, had information on liver histology obtained from liver biopsies and measures of hs-CRP and BMI. We investigated whether the different features of NAFLD and BMI were associated with hs-CRP, with and without mutual adjustments using linear regression. Results: BMI and hs-CRP were strongly associated. Per every 10% increase in BMI the hs-CRP level increased by 19-20% (p <0.001), and adjustment for NAFLD-stage (including no-NAFLD) did not influence the association. We found no BMI-independent association between NASH and hs-CRP. However, a positive association between degree of steatosis and hs-CRP was observed (p <0.05) and this effect remained significant after adjusting for BMI, lobular inflammation, hepatocyte ballooning, and fibrosis. We found no significant associations between the other features of NAFLD and hs-CRP. Conclusions: This study indicates that it is the accumulation of fat -both in the adipose tissue and in liver steatosis- that leads to increased hs-CRP levels among obese patients. Thus, hs-CRP may be a marker of steatosis, but not of severity of NAFLD, in obese patients.

AB - Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a major hepatic consequence of obesity. It has been suggested that the high sensitivity C-reactive protein (hs-CRP) is an obesity-independent surrogate marker of severity of NAFLD, especially development of non-alcoholic steato-hepatitis (NASH), but this remains controversial. We aimed to investigate whether associations between various features of NAFLD and hs-CRP are independent of body mass index (BMI) in its broad range among obese patients. Methods: A total of 627 obese adults (80% females), representing three cohorts from France and Belgium, had information on liver histology obtained from liver biopsies and measures of hs-CRP and BMI. We investigated whether the different features of NAFLD and BMI were associated with hs-CRP, with and without mutual adjustments using linear regression. Results: BMI and hs-CRP were strongly associated. Per every 10% increase in BMI the hs-CRP level increased by 19-20% (p <0.001), and adjustment for NAFLD-stage (including no-NAFLD) did not influence the association. We found no BMI-independent association between NASH and hs-CRP. However, a positive association between degree of steatosis and hs-CRP was observed (p <0.05) and this effect remained significant after adjusting for BMI, lobular inflammation, hepatocyte ballooning, and fibrosis. We found no significant associations between the other features of NAFLD and hs-CRP. Conclusions: This study indicates that it is the accumulation of fat -both in the adipose tissue and in liver steatosis- that leads to increased hs-CRP levels among obese patients. Thus, hs-CRP may be a marker of steatosis, but not of severity of NAFLD, in obese patients.

U2 - 10.1016/j.jhep.2010.12.017

DO - 10.1016/j.jhep.2010.12.017

M3 - Journal article

C2 - 21238518

SN - 0169-5185

VL - 55

SP - 660

EP - 665

JO - Journal of Hepatology, Supplement

JF - Journal of Hepatology, Supplement

IS - 3

ER -

C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

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