C-H functionalization on carbohydrates

TY - JOUR

T1 - C-H functionalization on carbohydrates

AU - Frihed, Tobias Gylling

AU - Bols, Mikael

AU - Pedersen, Christian Marcus

PY - 2016/6

Y1 - 2016/6

N2 - Functionalization of C–H bonds has received significant attention in organic chemistry during the last decade and it is still a “hot” topic. In particular, C–H modification of natural products has benefitted from this development. Carbohydrates are densely functionalized natural products, and methods for their functionalization are therefore very attractable. This review presents methods from the last five decades and gives an overview of the developments in C–H functionalization of carbohydrates. It covers all methods in which a C–H bond is broken: from radical abstractions and carbene insertion to new metal-catalyzed approaches. The review systematically covers the carbohydrates position-by-position and hence gives a quick overview.

AB - Functionalization of C–H bonds has received significant attention in organic chemistry during the last decade and it is still a “hot” topic. In particular, C–H modification of natural products has benefitted from this development. Carbohydrates are densely functionalized natural products, and methods for their functionalization are therefore very attractable. This review presents methods from the last five decades and gives an overview of the developments in C–H functionalization of carbohydrates. It covers all methods in which a C–H bond is broken: from radical abstractions and carbene insertion to new metal-catalyzed approaches. The review systematically covers the carbohydrates position-by-position and hence gives a quick overview.

U2 - 10.1002/ejoc.201600121

DO - 10.1002/ejoc.201600121

M3 - Review

SN - 1434-193X

VL - 2016

SP - 2740

EP - 2756

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 16

ER -