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Buccal absorption of diazepam is improved when administered in bioadhesive tablets-An in vivo study in conscious Göttingen mini-pigs
Emil Meng-Lund,
Jette Jacobsen
,
Anette Müllertz
, Erling B Jørgensen, René Holm
17
Citationer (Scopus)
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Keyphrases
Buccal Absorption
100%
Diazepam
100%
Chitosan
100%
Mucoadhesive Tablets
100%
Minipig
100%
Buccal Administration
33%
Slow Diffusion
33%
Absorption Rate
33%
Buccal mucosa
33%
Release Data
33%
Soluble Substances
33%
Solvation
33%
Mucoadhesive
33%
In Vivo Data
33%
Low Volume
33%
Buccal Delivery
33%
Tmax
33%
Crystalline Form
33%
Amorphous Form
33%
Systemic Absorption
33%
Saliva
33%
Gastrointestinal
33%
Potential Gains
33%
In Vitro Release
33%
Oral Bioavailability
33%
Immediate Release Tablets
33%
Pharmacology, Toxicology and Pharmaceutical Science
Diazepam
100%
Tablet
100%
Minipig
100%
Chitosan
50%
Bioavailability
33%
First Pass Effect
16%
Excipient
16%