@article{da6144e0acc711ddb538000ea68e967b,
title = "Brugada syndrome unmasked by accidental inhalation of gasoline vapors.",
abstract = "Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline vapors. His electrocardiogram (ECG) showed a typical type-1 BrS pattern that persisted after the acute event. Genetic investigations allowed the identification of a novel SCN5A mutation leading to a frame-shift and early termination of the channel protein. Biochemical and cellular electrophysiology experiments confirmed the loss-of-function of the mutant allele. The patient was implanted with a cardioverter/defibrillator.",
author = "Darko Kranjcec and Mijo Bergovec and Jean-S{\'e}bastien Rougier and Miroslav Raguz and Sonja Pavlovic and Thomas Jespersen and Vincent Castella and Keller, {Dagmar I} and Hugues Abriel",
note = "Keywords: Accidents, Occupational; Atrial Fibrillation; Brugada Syndrome; Gasoline; Humans; Inhalation; Male; Middle Aged",
year = "2007",
doi = "10.1111/j.1540-8159.2007.00857.x",
language = "English",
volume = "30",
pages = "1294--8",
journal = "PACE - Pacing and Clinical Electrophysiology",
issn = "0147-8389",
publisher = "Wiley-Blackwell",
number = "10",
}