Brain perfusion CT compared with ¹⁵O-H₂O PET in patients with primary brain tumours

TY - JOUR

T1 - Brain perfusion CT compared with ¹⁵O-H₂O PET in patients with primary brain tumours

AU - Grüner, Julie Marie

AU - Paamand, Rune Tore

AU - Kosteljanetz, Michael

AU - Broholm, Helle

AU - Højgaard, Liselotte

AU - Law, Ian

PY - 2012/11

Y1 - 2012/11

N2 - Purpose Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with 15 O-labelled water ( 15 OH 2 O). Methods On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naive primary brain tumours, twice using 15 O-H 2 O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. Results PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2± 18.8 ml min -1 100 ml -1 for PET and 78.9±41.8 ml min -1 100 ml -1 for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9±15.8 ml min -1 100 ml -1 for low-grade (WHO I + II) and 81.5±15.4 ml min -1 100 ml -1 for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients. Conclusion Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and 15 O-H 2 O PET in brain tumours.

AB - Purpose Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with 15 O-labelled water ( 15 OH 2 O). Methods On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naive primary brain tumours, twice using 15 O-H 2 O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. Results PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2± 18.8 ml min -1 100 ml -1 for PET and 78.9±41.8 ml min -1 100 ml -1 for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9±15.8 ml min -1 100 ml -1 for low-grade (WHO I + II) and 81.5±15.4 ml min -1 100 ml -1 for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients. Conclusion Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and 15 O-H 2 O PET in brain tumours.

U2 - 10.1007/s00259-012-2173-1

DO - 10.1007/s00259-012-2173-1

M3 - Journal article

C2 - 22736199

SN - 1619-7070

VL - 39

SP - 1691

EP - 1701

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 11

ER -