Brain expressed microRNAs implicated in schizophrenia etiology

Thomas Hansen; Line Olsen; Morten Lindow; Klaus D Jakobsen; Henrik Ullum; Erik Jonsson; Ole A Andreassen; Srdjan Djurovic; Ingrid Melle; Ingrid Agartz; Håkan Hall; Sally Timm; August G Wang; Thomas Werge

doi:http://dx.doi.org/10.1371/journal.pone.0000873

Brain expressed microRNAs implicated in schizophrenia etiology

Thomas Hansen, Line Olsen, Morten Lindow, Klaus D Jakobsen, Henrik Ullum, Erik Jonsson, Ole A Andreassen, Srdjan Djurovic, Ingrid Melle, Ingrid Agartz, Håkan Hall, Sally Timm, August G Wang, Thomas Werge

210 Citationer (Scopus)

Abstract

Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	2
Udgave nummer	9
Sider (fra-til)	e873
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0000873
Status	Udgivet - 2007

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http://dx.doi.org/10.1371/journal.pone.0000873

Citationsformater

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abstract = "Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.",

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T1 - Brain expressed microRNAs implicated in schizophrenia etiology

AU - Hansen, Thomas

AU - Olsen, Line

AU - Lindow, Morten

AU - Jakobsen, Klaus D

AU - Ullum, Henrik

AU - Jonsson, Erik

AU - Andreassen, Ole A

AU - Djurovic, Srdjan

AU - Melle, Ingrid

AU - Agartz, Ingrid

AU - Hall, Håkan

AU - Timm, Sally

AU - Wang, August G

AU - Werge, Thomas

PY - 2007

Y1 - 2007

N2 - Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.

AB - Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as candidates for schizophrenia-associated genetic factors. Indeed, the growing understanding of the regulatory properties and pleiotropic effects that miRNA have on molecular and cellular mechanisms, suggests that alterations in the interactions between miRNAs and their mRNA targets may contribute to phenotypic variation.

U2 - http://dx.doi.org/10.1371/journal.pone.0000873

DO - http://dx.doi.org/10.1371/journal.pone.0000873

M3 - Journal article

SN - 1932-6203

VL - 2

SP - e873

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 9

ER -

Brain expressed microRNAs implicated in schizophrenia etiology

Abstract

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