Abstract
Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid. These events are accompanied by changes in neuronal discharge patterns, astrocyte-neuron interactions, synaptic transactions and underlying metabolic features. Internally-generated neuronal activity and network homeostasis are proposed to account for the high sleep-related energy demand.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Current Opinion in Neurobiology |
| Vol/bind | 47 |
| Sider (fra-til) | 65-72 |
| Antal sider | 8 |
| ISSN | 0959-4388 |
| DOI | |
| Status | Udgivet - dec. 2017 |