Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics

A.B. Nejad; Bjørn Hylsebeck Ebdrup; Birte Yding Glenthøj; Hartwig Roman Siebner

doi:10.2174/157015912803217305

Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics

A.B. Nejad, Bjørn Hylsebeck Ebdrup, Birte Yding Glenthøj, Hartwig Roman Siebner

26 Citationer (Scopus)

Abstract

Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.

Originalsprog	Engelsk
Tidsskrift	Current Neuropharmacology
Vol/bind	10
Udgave nummer	3
Sider (fra-til)	219-230
Antal sider	12
ISSN	1570-159X
DOI	https://doi.org/10.2174/157015912803217305
Status	Udgivet - sep. 2012

Adgang til dokumentet

10.2174/157015912803217305

Citationsformater

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abstract = "Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.",

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AB - Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.

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