Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin

E M Pinholt; E Solheim; G Bang; E Sudmann

Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin

E M Pinholt, E Solheim, G Bang, E Sudmann

Sektion 04

28 Citationer (Scopus)

Abstract

Host tissue response and heterotopic osteoinduction by composites of demineralized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealant inhibited bone induction and produced a chronic inflammation; part of the fibrin-collagen paste was still present at 4 weeks. Polyorthoester with gentamicin was almost completely absorbed, induced minimal tissue reaction, and did not inhibit osteoinduction.

Originalsprog	Engelsk
Tidsskrift	Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Vol/bind	50
Udgave nummer	12
Sider (fra-til)	1300-4
Antal sider	5
Status	Udgivet - 1 dec. 1992

Citationsformater

Pinholt, E. M., Solheim, E., Bang, G., & Sudmann, E. (1992). Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 50(12), 1300-4.

Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin. / Pinholt, E M; Solheim, E; Bang, G et al.

I: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Bind 50, Nr. 12, 01.12.1992, s. 1300-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Pinholt, EM, Solheim, E, Bang, G & Sudmann, E 1992, 'Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin', Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, bind 50, nr. 12, s. 1300-4.

Pinholt EM, Solheim E, Bang G, Sudmann E. Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 1992 dec. 1;50(12):1300-4.

Pinholt, E M ; Solheim, E ; Bang, G et al. / Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin. I: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 1992 ; Bind 50, Nr. 12. s. 1300-4.

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title = "Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin",

abstract = "Host tissue response and heterotopic osteoinduction by composites of demineralized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealant inhibited bone induction and produced a chronic inflammation; part of the fibrin-collagen paste was still present at 4 weeks. Polyorthoester with gentamicin was almost completely absorbed, induced minimal tissue reaction, and did not inhibit osteoinduction.",

keywords = "Absorption, Animals, Biocompatible Materials, Bone Matrix, Collagen, Delayed-Action Preparations, Drug Carriers, Fibrin, Fibrin Tissue Adhesive, Gentamicins, Giant Cells, Macrophages, Male, Osteogenesis, Polyesters, Prostheses and Implants, Rats, Rats, Wistar, Skin",

author = "Pinholt, {E M} and E Solheim and G Bang and E Sudmann",

year = "1992",

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language = "English",

volume = "50",

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TY - JOUR

T1 - Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin

AU - Pinholt, E M

AU - Solheim, E

AU - Bang, G

AU - Sudmann, E

PY - 1992/12/1

Y1 - 1992/12/1

N2 - Host tissue response and heterotopic osteoinduction by composites of demineralized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealant inhibited bone induction and produced a chronic inflammation; part of the fibrin-collagen paste was still present at 4 weeks. Polyorthoester with gentamicin was almost completely absorbed, induced minimal tissue reaction, and did not inhibit osteoinduction.

AB - Host tissue response and heterotopic osteoinduction by composites of demineralized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealant inhibited bone induction and produced a chronic inflammation; part of the fibrin-collagen paste was still present at 4 weeks. Polyorthoester with gentamicin was almost completely absorbed, induced minimal tissue reaction, and did not inhibit osteoinduction.

KW - Absorption

KW - Animals

KW - Biocompatible Materials

KW - Bone Matrix

KW - Collagen

KW - Delayed-Action Preparations

KW - Drug Carriers

KW - Fibrin

KW - Fibrin Tissue Adhesive

KW - Gentamicins

KW - Giant Cells

KW - Macrophages

KW - Male

KW - Osteogenesis

KW - Polyesters

KW - Prostheses and Implants

KW - Rats

KW - Rats, Wistar

KW - Skin

M3 - Journal article

C2 - 1447610

SN - 0278-2391

VL - 50

SP - 1300

EP - 1304

JO - Journal of Oral and Maxillofacial Surgery

JF - Journal of Oral and Maxillofacial Surgery

IS - 12

ER -

Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin

Abstract

Fingeraftryk

Citationsformater