Body composition during early infancy and mental health outcomes at 5 years of age: A prospective cohort study of Ethiopian children

Mubarek Abera Mengistie; Markos Tesfaye; Charlotte Hanlon; Bitiya Admassu Wossen; Tsinuel Girma; Jonathan C Wells; Pernille Kæstel; Christian Ritz; Rasmus Wibæk Christensen; Kim F. Michaelsen; Henrik Friis; Gregers Stig Andersen

doi:10.1016/j.jpeds.2018.04.055

Body composition during early infancy and mental health outcomes at 5 years of age: A prospective cohort study of Ethiopian children

Mubarek Abera Mengistie, Markos Tesfaye, Charlotte Hanlon, Bitiya Admassu Wossen, Tsinuel Girma, Jonathan C Wells, Pernille Kæstel, Christian Ritz, Rasmus Wibæk Christensen, Kim F. Michaelsen, Henrik Friis, Gregers Stig Andersen

Ernæring og Sundhed hos børn og voksne

4 Citationer (Scopus)

Abstract

Objective: To examine the relationship between body composition-specifically fat mass (FM) and fat-free mass (FFM)-in early infancy, and mental health outcomes in early childhood.

Study design: In the Infant Anthropometry and Body Composition birth cohort study from Ethiopia, body composition was measured at birth and 1.5, 2.5, 3.5, 4.5, and 6 months of age. Mental health was assessed at 5 years of age using the approved Amharic version of the Strengths and Difficulties Questionnaire (SDQ), a parent report scale covering 4 different domains providing a total difficulties score. The associations of FM or FFM at birth as well as during early infancy, with SDQ score at 5 years of age were examined using multiple linear regression analyses.

Results: At 5 years of age, the mean ± SD for SDQ score was 10.4 ± 5.8. FM at birth was positively and FFM negatively associated with SDQ score. For each kg increase in FM at birth, the SDQ score at 5 years was 5.7 points higher (β = 5.7; 95% CI, 1.4-10.0). In contrast, for each kilogram increase in FFM at birth, the SDQ score was 3.9 points lower (β = -3.9; 95% CI, -7.0 to -0.8). Neither FM nor FFM accretion rate during early infancy were associated with SDQ score at 5 years of age.

Conclusions Fetal rather than infant body composition was associated with SDQ score at 5 years of age. Greater FFM accretion during fetal life may have contributed to more optimal neurobehavioral development during early life. However, the potential mechanisms underlying the observed associations need further investigation.

Originalsprog	Engelsk
Tidsskrift	Journal of Pediatrics
Vol/bind	200
Sider (fra-til)	225-231
Antal sider	7
ISSN	0022-3476
DOI	https://doi.org/10.1016/j.jpeds.2018.04.055
Status	Udgivet - sep. 2018

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10.1016/j.jpeds.2018.04.055

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Abera Mengistie, M., Tesfaye, M., Hanlon, C., Admassu Wossen, B., Girma, T., Wells, J. C., Kæstel, P., Ritz, C., Wibæk Christensen, R., Michaelsen, K. F., Friis, H., & Andersen, G. S. (2018). Body composition during early infancy and mental health outcomes at 5 years of age: A prospective cohort study of Ethiopian children. Journal of Pediatrics, 200, 225-231. https://doi.org/10.1016/j.jpeds.2018.04.055

Abera Mengistie, M, Tesfaye, M, Hanlon, C, Admassu Wossen, B, Girma, T, Wells, JC, Kæstel, P, Ritz, C, Wibæk Christensen, R, Michaelsen, KF , Friis, H & Andersen, GS 2018, 'Body composition during early infancy and mental health outcomes at 5 years of age: A prospective cohort study of Ethiopian children', Journal of Pediatrics, bind 200, s. 225-231. https://doi.org/10.1016/j.jpeds.2018.04.055

@article{a166e3ca17624ec995af761ae75f3930,

title = "Body composition during early infancy and mental health outcomes at 5 years of age: A prospective cohort study of Ethiopian children",

abstract = "Objective: To examine the relationship between body composition-specifically fat mass (FM) and fat-free mass (FFM)-in early infancy, and mental health outcomes in early childhood.Study design: In the Infant Anthropometry and Body Composition birth cohort study from Ethiopia, body composition was measured at birth and 1.5, 2.5, 3.5, 4.5, and 6 months of age. Mental health was assessed at 5 years of age using the approved Amharic version of the Strengths and Difficulties Questionnaire (SDQ), a parent report scale covering 4 different domains providing a total difficulties score. The associations of FM or FFM at birth as well as during early infancy, with SDQ score at 5 years of age were examined using multiple linear regression analyses.Results: At 5 years of age, the mean ± SD for SDQ score was 10.4 ± 5.8. FM at birth was positively and FFM negatively associated with SDQ score. For each kg increase in FM at birth, the SDQ score at 5 years was 5.7 points higher (β = 5.7; 95% CI, 1.4-10.0). In contrast, for each kilogram increase in FFM at birth, the SDQ score was 3.9 points lower (β = -3.9; 95% CI, -7.0 to -0.8). Neither FM nor FFM accretion rate during early infancy were associated with SDQ score at 5 years of age.Conclusions Fetal rather than infant body composition was associated with SDQ score at 5 years of age. Greater FFM accretion during fetal life may have contributed to more optimal neurobehavioral development during early life. However, the potential mechanisms underlying the observed associations need further investigation.",

keywords = "Faculty of Science, Body composition, Fat mass, Fat-free mass, Mental health outcome, Child mental health",

author = "{Abera Mengistie}, Mubarek and Markos Tesfaye and Charlotte Hanlon and {Admassu Wossen}, Bitiya and Tsinuel Girma and Wells, {Jonathan C} and Pernille K{\ae}stel and Christian Ritz and {Wib{\ae}k Christensen}, Rasmus and Michaelsen, {Kim F.} and Henrik Friis and Andersen, {Gregers Stig}",

note = "CURIS 2018 NEXS 245",

year = "2018",

month = sep,

doi = "10.1016/j.jpeds.2018.04.055",

language = "English",

volume = "200",

pages = "225--231",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Body composition during early infancy and mental health outcomes at 5 years of age

T2 - A prospective cohort study of Ethiopian children

AU - Abera Mengistie, Mubarek

AU - Tesfaye, Markos

AU - Hanlon, Charlotte

AU - Admassu Wossen, Bitiya

AU - Girma, Tsinuel

AU - Wells, Jonathan C

AU - Kæstel, Pernille

AU - Ritz, Christian

AU - Wibæk Christensen, Rasmus

AU - Michaelsen, Kim F.

AU - Friis, Henrik

AU - Andersen, Gregers Stig

N1 - CURIS 2018 NEXS 245

PY - 2018/9

Y1 - 2018/9

N2 - Objective: To examine the relationship between body composition-specifically fat mass (FM) and fat-free mass (FFM)-in early infancy, and mental health outcomes in early childhood.Study design: In the Infant Anthropometry and Body Composition birth cohort study from Ethiopia, body composition was measured at birth and 1.5, 2.5, 3.5, 4.5, and 6 months of age. Mental health was assessed at 5 years of age using the approved Amharic version of the Strengths and Difficulties Questionnaire (SDQ), a parent report scale covering 4 different domains providing a total difficulties score. The associations of FM or FFM at birth as well as during early infancy, with SDQ score at 5 years of age were examined using multiple linear regression analyses.Results: At 5 years of age, the mean ± SD for SDQ score was 10.4 ± 5.8. FM at birth was positively and FFM negatively associated with SDQ score. For each kg increase in FM at birth, the SDQ score at 5 years was 5.7 points higher (β = 5.7; 95% CI, 1.4-10.0). In contrast, for each kilogram increase in FFM at birth, the SDQ score was 3.9 points lower (β = -3.9; 95% CI, -7.0 to -0.8). Neither FM nor FFM accretion rate during early infancy were associated with SDQ score at 5 years of age.Conclusions Fetal rather than infant body composition was associated with SDQ score at 5 years of age. Greater FFM accretion during fetal life may have contributed to more optimal neurobehavioral development during early life. However, the potential mechanisms underlying the observed associations need further investigation.

AB - Objective: To examine the relationship between body composition-specifically fat mass (FM) and fat-free mass (FFM)-in early infancy, and mental health outcomes in early childhood.Study design: In the Infant Anthropometry and Body Composition birth cohort study from Ethiopia, body composition was measured at birth and 1.5, 2.5, 3.5, 4.5, and 6 months of age. Mental health was assessed at 5 years of age using the approved Amharic version of the Strengths and Difficulties Questionnaire (SDQ), a parent report scale covering 4 different domains providing a total difficulties score. The associations of FM or FFM at birth as well as during early infancy, with SDQ score at 5 years of age were examined using multiple linear regression analyses.Results: At 5 years of age, the mean ± SD for SDQ score was 10.4 ± 5.8. FM at birth was positively and FFM negatively associated with SDQ score. For each kg increase in FM at birth, the SDQ score at 5 years was 5.7 points higher (β = 5.7; 95% CI, 1.4-10.0). In contrast, for each kilogram increase in FFM at birth, the SDQ score was 3.9 points lower (β = -3.9; 95% CI, -7.0 to -0.8). Neither FM nor FFM accretion rate during early infancy were associated with SDQ score at 5 years of age.Conclusions Fetal rather than infant body composition was associated with SDQ score at 5 years of age. Greater FFM accretion during fetal life may have contributed to more optimal neurobehavioral development during early life. However, the potential mechanisms underlying the observed associations need further investigation.

KW - Faculty of Science

KW - Body composition

KW - Fat mass

KW - Fat-free mass

KW - Mental health outcome

KW - Child mental health

U2 - 10.1016/j.jpeds.2018.04.055

DO - 10.1016/j.jpeds.2018.04.055

M3 - Journal article

C2 - 30060887

SN - 0022-3476

VL - 200

SP - 225

EP - 231

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Body composition during early infancy and mental health outcomes at 5 years of age: A prospective cohort study of Ethiopian children

Abstract

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