Bistability in autoimmune diseases

Nicolas Philippe Jean-Pierre Rapin; Erik Mosekilde; Ole Lund

doi:10.3109/08916934.2010.523233

Bistability in autoimmune diseases

Nicolas Philippe Jean-Pierre Rapin, Erik Mosekilde, Ole Lund

Bioinformatik og RNA Biologi

8 Citationer (Scopus)

Abstract

Autoimmune diseases damage host tissue, which, in turn, may trigger a stronger immune response. Systems characterized by such positive feedback loops can display co-existing stable steady states. In a mathematical model of autoimmune disease, one steady state may correspond to the healthy state and another to an autoimmune steady state characterized by widespread tissue damage and immune activation. We show how a triggering event may move the system from the healthy to the autoimmune state and how transient immunosuppressive treatment can move the system back to the healthy state.

Originalsprog	Engelsk
Tidsskrift	Autoimmunity
Vol/bind	44
Udgave nummer	4
Sider (fra-til)	256-260
Antal sider	5
ISSN	0891-6934
DOI	https://doi.org/10.3109/08916934.2010.523233
Status	Udgivet - jun. 2011

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10.3109/08916934.2010.523233

Citationsformater

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title = "Bistability in autoimmune diseases",

abstract = "Autoimmune diseases damage host tissue, which, in turn, may trigger a stronger immune response. Systems characterized by such positive feedback loops can display co-existing stable steady states. In a mathematical model of autoimmune disease, one steady state may correspond to the healthy state and another to an autoimmune steady state characterized by widespread tissue damage and immune activation. We show how a triggering event may move the system from the healthy to the autoimmune state and how transient immunosuppressive treatment can move the system back to the healthy state.",

keywords = "Autoimmune Diseases, Homeostasis, Humans, Models, Immunological",

author = "Rapin, {Nicolas Philippe Jean-Pierre} and Erik Mosekilde and Ole Lund",

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T1 - Bistability in autoimmune diseases

AU - Rapin, Nicolas Philippe Jean-Pierre

AU - Mosekilde, Erik

AU - Lund, Ole

PY - 2011/6

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N2 - Autoimmune diseases damage host tissue, which, in turn, may trigger a stronger immune response. Systems characterized by such positive feedback loops can display co-existing stable steady states. In a mathematical model of autoimmune disease, one steady state may correspond to the healthy state and another to an autoimmune steady state characterized by widespread tissue damage and immune activation. We show how a triggering event may move the system from the healthy to the autoimmune state and how transient immunosuppressive treatment can move the system back to the healthy state.

AB - Autoimmune diseases damage host tissue, which, in turn, may trigger a stronger immune response. Systems characterized by such positive feedback loops can display co-existing stable steady states. In a mathematical model of autoimmune disease, one steady state may correspond to the healthy state and another to an autoimmune steady state characterized by widespread tissue damage and immune activation. We show how a triggering event may move the system from the healthy to the autoimmune state and how transient immunosuppressive treatment can move the system back to the healthy state.

KW - Autoimmune Diseases

KW - Homeostasis

KW - Humans

KW - Models, Immunological

U2 - 10.3109/08916934.2010.523233

DO - 10.3109/08916934.2010.523233

M3 - Journal article

C2 - 21244341

SN - 0891-6934

VL - 44

SP - 256

EP - 260

JO - Autoimmunity

JF - Autoimmunity

IS - 4

ER -

Bistability in autoimmune diseases

Abstract

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