Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)

Marie Pedersen; Hans von Stedingk; Maria Botsivali; Silvia Agramunt; Jan Alexander; Gunnar Brunborg; Leda Chatzi; Sarah Fleming; Eleni Fthenou; Berit Granum; Kristine B Gutzkow; Laura J Hardie; Lisbeth E Knudsen; Soterios A Kyrtopoulos; Michelle A Mendez; Domenico F Merlo; Jeanette K Nielsen; Per Rydberg; Dan Segerbäck; Jordi Sunyer; John Wright; Margareta Törnqvist; Jos C Kleinjans; Manolis Kogevinas; NewGeneris Consortium

doi:10.1289/ehp.1205327

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)

Marie Pedersen, Hans von Stedingk, Maria Botsivali, Silvia Agramunt, Jan Alexander, Gunnar Brunborg, Leda Chatzi, Sarah Fleming, Eleni Fthenou, Berit Granum, Kristine B Gutzkow, Laura J Hardie, Lisbeth E Knudsen, Soterios A Kyrtopoulos, Michelle A Mendez, Domenico F Merlo, Jeanette K Nielsen, Per Rydberg, Dan Segerbäck, Jordi SunyerJohn Wright, Margareta Törnqvist, Jos C Kleinjans, Manolis Kogevinas, NewGeneris Consortium

69 Citationer (Scopus)

Abstract

Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the associations between prenatal exposure to acrylamide and birth out-comes in a prospective European mother-child study. Methods: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. Results: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. Conclusions: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure inutero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.

Originalsprog	Engelsk
Tidsskrift	Environmental Health Perspectives
Vol/bind	120
Udgave nummer	12
Sider (fra-til)	1739-45
Antal sider	7
ISSN	0091-6765
DOI	https://doi.org/10.1289/ehp.1205327
Status	Udgivet - dec. 2012

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10.1289/ehp.1205327

Citationsformater

Pedersen, M., von Stedingk, H., Botsivali, M., Agramunt, S., Alexander, J., Brunborg, G., Chatzi, L., Fleming, S., Fthenou, E., Granum, B., Gutzkow, K. B., Hardie, L. J., Knudsen, L. E., Kyrtopoulos, S. A., Mendez, M. A., Merlo, D. F., Nielsen, J. K., Rydberg, P., Segerbäck, D., ... NewGeneris Consortium (2012). Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris). Environmental Health Perspectives, 120(12), 1739-45. https://doi.org/10.1289/ehp.1205327

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris). / Pedersen, Marie; von Stedingk, Hans; Botsivali, Maria et al.
I: Environmental Health Perspectives, Bind 120, Nr. 12, 12.2012, s. 1739-45.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Pedersen, M, von Stedingk, H, Botsivali, M, Agramunt, S, Alexander, J, Brunborg, G, Chatzi, L, Fleming, S, Fthenou, E, Granum, B, Gutzkow, KB, Hardie, LJ, Knudsen, LE, Kyrtopoulos, SA, Mendez, MA, Merlo, DF, Nielsen, JK, Rydberg, P, Segerbäck, D, Sunyer, J, Wright, J, Törnqvist, M, Kleinjans, JC, Kogevinas, M & NewGeneris Consortium 2012, 'Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)', Environmental Health Perspectives, bind 120, nr. 12, s. 1739-45. https://doi.org/10.1289/ehp.1205327

@article{6dedb5f674a34adcac89cf68dd6b0516,

title = "Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)",

abstract = "Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the associations between prenatal exposure to acrylamide and birth out-comes in a prospective European mother-child study. Methods: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. Results: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. Conclusions: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure inutero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.",

author = "Marie Pedersen and {von Stedingk}, Hans and Maria Botsivali and Silvia Agramunt and Jan Alexander and Gunnar Brunborg and Leda Chatzi and Sarah Fleming and Eleni Fthenou and Berit Granum and Gutzkow, {Kristine B} and Hardie, {Laura J} and Knudsen, {Lisbeth E} and Kyrtopoulos, {Soterios A} and Mendez, {Michelle A} and Merlo, {Domenico F} and Nielsen, {Jeanette K} and Per Rydberg and Dan Segerb{\"a}ck and Jordi Sunyer and John Wright and Margareta T{\"o}rnqvist and Kleinjans, {Jos C} and Manolis Kogevinas and {NewGeneris Consortium}",

year = "2012",

month = dec,

doi = "10.1289/ehp.1205327",

language = "English",

volume = "120",

pages = "1739--45",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "National Institute of Environmental Health Sciences",

number = "12",

}

TY - JOUR

T1 - Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet

T2 - the European prospective mother-child study (NewGeneris)

AU - Pedersen, Marie

AU - von Stedingk, Hans

AU - Botsivali, Maria

AU - Agramunt, Silvia

AU - Alexander, Jan

AU - Brunborg, Gunnar

AU - Chatzi, Leda

AU - Fleming, Sarah

AU - Fthenou, Eleni

AU - Granum, Berit

AU - Gutzkow, Kristine B

AU - Hardie, Laura J

AU - Knudsen, Lisbeth E

AU - Kyrtopoulos, Soterios A

AU - Mendez, Michelle A

AU - Merlo, Domenico F

AU - Nielsen, Jeanette K

AU - Rydberg, Per

AU - Segerbäck, Dan

AU - Sunyer, Jordi

AU - Wright, John

AU - Törnqvist, Margareta

AU - Kleinjans, Jos C

AU - Kogevinas, Manolis

AU - NewGeneris Consortium

PY - 2012/12

Y1 - 2012/12

N2 - Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the associations between prenatal exposure to acrylamide and birth out-comes in a prospective European mother-child study. Methods: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. Results: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. Conclusions: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure inutero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.

AB - Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. Objectives: We examined the associations between prenatal exposure to acrylamide and birth out-comes in a prospective European mother-child study. Methods: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. Results: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. Conclusions: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure inutero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.

U2 - 10.1289/ehp.1205327

DO - 10.1289/ehp.1205327

M3 - Journal article

C2 - 23092936

SN - 0091-6765

VL - 120

SP - 1739

EP - 1745

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 12

ER -

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)

Abstract

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