Biomarkører ved diagnostik af Alzheimers sygdom i tidlig fase

TY - JOUR

T1 - Biomarkører ved diagnostik af Alzheimers sygdom i tidlig fase

AU - Frederiksen, Kristian S

AU - Hasselbalch, Steen

AU - Law, Ian

AU - Højgaard, Liselotte

AU - Waldemar, Gunhild

PY - 2015/6/8

Y1 - 2015/6/8

N2 - Alzheimer's disease is responsible for 40-50% of dementia cases. Future treatment may include disease-modifying compounds unlikely to be efficient if administered late in the course, thus necessitating early diagnosis. Furthermore, revised diagnostic research criteria that include biomarkers of pathological accumulation of cortical beta-amyloid (decreased beta-amyloid in cerebrospinal fluid and amyloid imaging) and neurodegeneration (structural MRI and 18F-FDG-PET), have been published. Future research is needed to determine specific evidence-based application of these biomarkers in the clinic as well as discovery of novel biomarkers.

AB - Alzheimer's disease is responsible for 40-50% of dementia cases. Future treatment may include disease-modifying compounds unlikely to be efficient if administered late in the course, thus necessitating early diagnosis. Furthermore, revised diagnostic research criteria that include biomarkers of pathological accumulation of cortical beta-amyloid (decreased beta-amyloid in cerebrospinal fluid and amyloid imaging) and neurodegeneration (structural MRI and 18F-FDG-PET), have been published. Future research is needed to determine specific evidence-based application of these biomarkers in the clinic as well as discovery of novel biomarkers.

M3 - Tidsskriftartikel

C2 - 26058526

SN - 0041-5782

VL - 177

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 24

M1 - V12140684

ER -