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Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5
Jon Valgeirsson, Elsebet O Nielsen, Dan Peters, Claus Mathiesen,
Anders S Kristensen
,
Ulf Madsen
Institut for Klinisk Medicin
Institut for Tværkulturelle og Regionale Studier
41
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Keyphrases
Competitive Antagonist
100%
Homomeric
100%
IC50
25%
IC50 Value
25%
In Vivo Activity
25%
Kainate Receptor
100%
Linker
75%
Metabotropic Glutamate Receptor 5 (mGluR5)
100%
Non-competitive
25%
Receptor Subtypes
100%
Structure-activity Relationship
25%
Sulfonic Acid
25%
Tetrazole
25%
Urea
50%
Pharmacology, Toxicology and Pharmaceutical Science
Alpha Amino 5 Tert Butyl 3 Hydroxy 4 Isoxazolepropionic Acid
50%
Kainic Acid Receptor
100%
Receptor
100%
Receptor Subtype
100%
Structure Activity Relationship
50%
Sulfonic Acid
50%
Tetrazole Derivative
50%