Biochemical and Clinical Effect of Ovarian Wedge Resection in the Polycystic Ovary Syndrome.

TY - JOUR

T1 - Biochemical and Clinical Effect of Ovarian Wedge Resection in the Polycystic Ovary Syndrome.

AU - Vejlsted, H

AU - Albrechtsen, R

N1 - Keywords: 17-Ketosteroids; Adolescent; Adrenal Cortex Function Tests; Adult; Androgens; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Female; Humans; Ovarian Function Tests; Ovary; Polycystic Ovary Syndrome; Pregnancy; Testosterone

PY - 1976

Y1 - 1976

N2 - Twelve patients with histologically verified polycystic ovary syndrome were investigated with special regard given to the effect of wedge resection on androgen status. Adrenal disorders were excluded in every case by determination of cortisol and corticosterone metabolites. Prior to and at least 6 months after surgery all patients were subjected to adrenal stimulation followed by adrenal suppression and ovarian stimulation. Comparison between pre- and postoperative studies revealed that only an insignificant reduction in the excretion of 17-ketosteroid had occurred and, although at lower levels, the stimulatory effect of hCG on ovarian androgens was still present. Clinically, 10 patients had had regular periods at followup, and 3 had become pregnant. In no case had hair growth slowed, bu the rate had declined. Seemingly, wedge resection does not significantly influence the biochemical pattern connected with the polycystic ovary syndrome.

AB - Twelve patients with histologically verified polycystic ovary syndrome were investigated with special regard given to the effect of wedge resection on androgen status. Adrenal disorders were excluded in every case by determination of cortisol and corticosterone metabolites. Prior to and at least 6 months after surgery all patients were subjected to adrenal stimulation followed by adrenal suppression and ovarian stimulation. Comparison between pre- and postoperative studies revealed that only an insignificant reduction in the excretion of 17-ketosteroid had occurred and, although at lower levels, the stimulatory effect of hCG on ovarian androgens was still present. Clinically, 10 patients had had regular periods at followup, and 3 had become pregnant. In no case had hair growth slowed, bu the rate had declined. Seemingly, wedge resection does not significantly influence the biochemical pattern connected with the polycystic ovary syndrome.

M3 - Journal article

C2 - 131263

SN - 0029-7844

VL - 47

SP - 575

EP - 580

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

IS - 5

ER -