Bioavailability of the antiemetic metopimazine given as a microenema

TY - JOUR

T1 - Bioavailability of the antiemetic metopimazine given as a microenema

AU - Herrstedt, J.

AU - Jørgensen, M.

AU - Angelo, H.R.

AU - Rassing, M.R.

AU - Sonnergaard, Jørn

AU - Dombernowsky, P.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bioavailability of MPZ given orally and as enemas was 22.3 and 19.5% respectively. Partial avoidance of hepatic first pass metabolism was seen with the enemas, which in contrast to suppositories, seems to represent a reliable form of rectal administration.

AB - The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bioavailability of MPZ given orally and as enemas was 22.3 and 19.5% respectively. Partial avoidance of hepatic first pass metabolism was seen with the enemas, which in contrast to suppositories, seems to represent a reliable form of rectal administration.

UR - http://www.scopus.com/inward/record.url?scp=0029989837&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0029989837

SN - 0306-5251

VL - 41

SP - 613

EP - 615

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 6

ER -