Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Kristian Klemp; Jens Folke Kiilgaard; Steffen Heegaard; Tove Nørgaard; Mette Klarskov Andersen; Jan Ulrik Prause

doi:10.1111/aos.13481

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Kristian Klemp^*, Jens Folke Kiilgaard, Steffen Heegaard, Tove Nørgaard, Mette Klarskov Andersen, Jan Ulrik Prause

^*Corresponding author af dette arbejde

12 Citationer (Scopus)

Abstract

Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.

Originalsprog	Engelsk
Tidsskrift	Acta Ophthalmologica
Vol/bind	95
Udgave nummer	5
Sider (fra-til)	439-445
Antal sider	7
ISSN	1755-375X
DOI	https://doi.org/10.1111/aos.13481
Status	Udgivet - 2017

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10.1111/aos.13481

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Citationsformater

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abstract = "Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.",

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T1 - Bilateral diffuse uveal melanocytic proliferation

T2 - Case report and literature review

AU - Klemp, Kristian

AU - Kiilgaard, Jens Folke

AU - Heegaard, Steffen

AU - Nørgaard, Tove

AU - Andersen, Mette Klarskov

AU - Prause, Jan Ulrik

PY - 2017

Y1 - 2017

N2 - Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.

AB - Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.

KW - bilateral

KW - diffuse

KW - melanocytic

KW - proliferation

KW - uveal

U2 - 10.1111/aos.13481

DO - 10.1111/aos.13481

M3 - Review

C2 - 28636126

AN - SCOPUS:85021096402

SN - 1755-375X

VL - 95

SP - 439

EP - 445

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

IS - 5

ER -

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Abstract

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