Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms

Mads Frederik Hansen; Sine Lo Svenningsen; Henriette Lyng Røder; Mathias Middelboe; Mette Burmølle

doi:10.1016/j.tim.2019.04.006

Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms

Mads Frederik Hansen, Sine Lo Svenningsen, Henriette Lyng Røder, Mathias Middelboe^*, Mette Burmølle

^*Corresponding author af dette arbejde

24 Citationer (Scopus)

Abstract

Bacteriophages (phages) have been shaping bacterial ecology and evolution for millions of years, for example, by selecting for defence strategies. Evidence supports that bacterial biofilm formation is one such strategy and that biofilm-mediated protection against phage infection depends on maturation and composition of the extracellular matrix. Interestingly, studies have revealed that phages can induce and strengthen biofilms. Here we review interactions between bacteria and phages in biofilms, discuss the underlying mechanisms, the potential of phage therapy for biofilm control, and emphasize the importance of considering biofilms in future phage research. This is especially relevant as biofilms are associated with increased tolerance towards antibiotics and are implicated in the majority of chronic infections.

Originalsprog	Engelsk
Tidsskrift	Trends in Microbiology
Vol/bind	27
Udgave nummer	9
Sider (fra-til)	739-752
Antal sider	14
ISSN	0966-842X
DOI	https://doi.org/10.1016/j.tim.2019.04.006
Status	Udgivet - sep. 2019

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10.1016/j.tim.2019.04.006

Citationsformater

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title = "Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms",

abstract = "Bacteriophages (phages) have been shaping bacterial ecology and evolution for millions of years, for example, by selecting for defence strategies. Evidence supports that bacterial biofilm formation is one such strategy and that biofilm-mediated protection against phage infection depends on maturation and composition of the extracellular matrix. Interestingly, studies have revealed that phages can induce and strengthen biofilms. Here we review interactions between bacteria and phages in biofilms, discuss the underlying mechanisms, the potential of phage therapy for biofilm control, and emphasize the importance of considering biofilms in future phage research. This is especially relevant as biofilms are associated with increased tolerance towards antibiotics and are implicated in the majority of chronic infections.",

keywords = "bacteriophage–bacteria interactions, biofilms, evolution, extracellular matrix, phage therapy, quorum sensing",

author = "Hansen, {Mads Frederik} and Svenningsen, {Sine Lo} and R{\o}der, {Henriette Lyng} and Mathias Middelboe and Mette Burm{\o}lle",

year = "2019",

month = sep,

doi = "10.1016/j.tim.2019.04.006",

language = "English",

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T1 - Big Impact of the Tiny

T2 - Bacteriophage–Bacteria Interactions in Biofilms

AU - Hansen, Mads Frederik

AU - Svenningsen, Sine Lo

AU - Røder, Henriette Lyng

AU - Middelboe, Mathias

AU - Burmølle, Mette

PY - 2019/9

Y1 - 2019/9

N2 - Bacteriophages (phages) have been shaping bacterial ecology and evolution for millions of years, for example, by selecting for defence strategies. Evidence supports that bacterial biofilm formation is one such strategy and that biofilm-mediated protection against phage infection depends on maturation and composition of the extracellular matrix. Interestingly, studies have revealed that phages can induce and strengthen biofilms. Here we review interactions between bacteria and phages in biofilms, discuss the underlying mechanisms, the potential of phage therapy for biofilm control, and emphasize the importance of considering biofilms in future phage research. This is especially relevant as biofilms are associated with increased tolerance towards antibiotics and are implicated in the majority of chronic infections.

AB - Bacteriophages (phages) have been shaping bacterial ecology and evolution for millions of years, for example, by selecting for defence strategies. Evidence supports that bacterial biofilm formation is one such strategy and that biofilm-mediated protection against phage infection depends on maturation and composition of the extracellular matrix. Interestingly, studies have revealed that phages can induce and strengthen biofilms. Here we review interactions between bacteria and phages in biofilms, discuss the underlying mechanisms, the potential of phage therapy for biofilm control, and emphasize the importance of considering biofilms in future phage research. This is especially relevant as biofilms are associated with increased tolerance towards antibiotics and are implicated in the majority of chronic infections.

KW - bacteriophage–bacteria interactions

KW - biofilms

KW - evolution

KW - extracellular matrix

KW - phage therapy

KW - quorum sensing

U2 - 10.1016/j.tim.2019.04.006

DO - 10.1016/j.tim.2019.04.006

M3 - Review

C2 - 31128928

AN - SCOPUS:85065885980

SN - 0966-842X

VL - 27

SP - 739

EP - 752

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 9

ER -

Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms

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