Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC

TY - JOUR

T1 - Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC

AU - Ullum, H.

AU - Haahr, P. M.

AU - Diamant, M.

AU - Palmo, J.

AU - Halkjaer-Kristensen, J.

AU - Pedersen, B. K.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The present study investigated the effect of concentric exercise on cytokine plasma levels and cytokine pre-mRNA in blood mononuclear cells (BMNCs). Healthy young moderately trained men performed ergometer bicycle exercise for 1 h at 75% of maximal oxygen uptake. The levels of plasma interleukin (IL)-6 increased significantly during exercise, but plasma levels of IL-1α, IL-1β, and tumor necrosis factor-α (TNF-α) were below the detection limit in most subjects. Pre-mRNA for IL-1α, IL-1β, IL-6, and TNF- α could be detected in BMNCs, but the amounts did not change in relation to exercise. These results indicate that, although the absolute number of monocytes increases during exercise and the percentage of CD14+/HLA-DR+ and CD14+/HLA-DR- monocytes increases after exercise, the increased plasma levels of IL-6 during exercise is not likely to be a result of activated monocytes in peripheral blood.

AB - The present study investigated the effect of concentric exercise on cytokine plasma levels and cytokine pre-mRNA in blood mononuclear cells (BMNCs). Healthy young moderately trained men performed ergometer bicycle exercise for 1 h at 75% of maximal oxygen uptake. The levels of plasma interleukin (IL)-6 increased significantly during exercise, but plasma levels of IL-1α, IL-1β, and tumor necrosis factor-α (TNF-α) were below the detection limit in most subjects. Pre-mRNA for IL-1α, IL-1β, IL-6, and TNF- α could be detected in BMNCs, but the amounts did not change in relation to exercise. These results indicate that, although the absolute number of monocytes increases during exercise and the percentage of CD14+/HLA-DR+ and CD14+/HLA-DR- monocytes increases after exercise, the increased plasma levels of IL-6 during exercise is not likely to be a result of activated monocytes in peripheral blood.

KW - cytokines

KW - immunology

KW - lymphocytes

KW - monocytes

KW - sport

KW - stress

UR - http://www.scopus.com/inward/record.url?scp=0028276385&partnerID=8YFLogxK

U2 - 10.1152/jappl.1994.77.1.93

DO - 10.1152/jappl.1994.77.1.93

M3 - Journal article

C2 - 7961280

AN - SCOPUS:0028276385

SN - 8750-7587

VL - 77

SP - 93

EP - 97

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

IS - 1

ER -