Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

TY - JOUR

T1 - Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

AU - Castle, Sherry A

AU - Owuor, Elizabeth A

AU - Thompson, Stephanie H

AU - Garnsey, Michelle R

AU - Klutts, J Stacey

AU - Doering, Tamara L

AU - Levery, Steven B

PY - 2008/9

Y1 - 2008/9

N2 - The Manalpha1,3(Xylbeta1,2)Manalpha structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylbeta1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

AB - The Manalpha1,3(Xylbeta1,2)Manalpha structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylbeta1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

KW - Cryptococcus neoformans

KW - Fungal Proteins

KW - Glycosphingolipids

KW - Pentosyltransferases

KW - Xylose

U2 - 10.1128/EC.00458-07

DO - 10.1128/EC.00458-07

M3 - Journal article

C2 - 18676952

SN - 2379-5042

VL - 7

SP - 1611

EP - 1615

JO - mSphere

JF - mSphere

IS - 9

ER -