Benzoxazoles and oxazolopyridines in medicinal chemistry studies

Charles S Demmer; Lennart Bunch

doi:10.1016/j.ejmech.2014.11.064

Benzoxazoles and oxazolopyridines in medicinal chemistry studies

79 Citationer (Scopus)

Abstract

The benzoxazole heterocycle is often found in ligands targeting a plethora of receptors and enzymes. By analysis of published X-ray structures, this review aims at highlighting key interactions which the benzoxazole may engage in with its host protein. Furthermore, bioavailability, metabolism and the use of benzoxazole as a bioisostere are discussed. The review is extended to cover structure-activity relationship studies of 2-substituted benzoxazoles, 2-substituted oxazolopyridines, and in perspective, application of the recently published novel heterocycle oxazolopyrazine in medicinal chemistry studies.

Originalsprog	Engelsk
Tidsskrift	European Journal of Medicinal Chemistry
Vol/bind	97
Sider (fra-til)	778-785
Antal sider	8
ISSN	0223-5234
DOI	https://doi.org/10.1016/j.ejmech.2014.11.064
Status	Udgivet - 2015

Adgang til dokumentet

10.1016/j.ejmech.2014.11.064

Citationsformater

@article{c4654ad7d6e145d4898d1001526f4157,

title = "Benzoxazoles and oxazolopyridines in medicinal chemistry studies",

abstract = "The benzoxazole heterocycle is often found in ligands targeting a plethora of receptors and enzymes. By analysis of published X-ray structures, this review aims at highlighting key interactions which the benzoxazole may engage in with its host protein. Furthermore, bioavailability, metabolism and the use of benzoxazole as a bioisostere are discussed. The review is extended to cover structure-activity relationship studies of 2-substituted benzoxazoles, 2-substituted oxazolopyridines, and in perspective, application of the recently published novel heterocycle oxazolopyrazine in medicinal chemistry studies.",

author = "Demmer, {Charles S} and Lennart Bunch",

year = "2015",

doi = "10.1016/j.ejmech.2014.11.064",

language = "English",

volume = "97",

pages = "778--785",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson",

}

TY - JOUR

T1 - Benzoxazoles and oxazolopyridines in medicinal chemistry studies

AU - Demmer, Charles S

AU - Bunch, Lennart

PY - 2015

Y1 - 2015

N2 - The benzoxazole heterocycle is often found in ligands targeting a plethora of receptors and enzymes. By analysis of published X-ray structures, this review aims at highlighting key interactions which the benzoxazole may engage in with its host protein. Furthermore, bioavailability, metabolism and the use of benzoxazole as a bioisostere are discussed. The review is extended to cover structure-activity relationship studies of 2-substituted benzoxazoles, 2-substituted oxazolopyridines, and in perspective, application of the recently published novel heterocycle oxazolopyrazine in medicinal chemistry studies.

AB - The benzoxazole heterocycle is often found in ligands targeting a plethora of receptors and enzymes. By analysis of published X-ray structures, this review aims at highlighting key interactions which the benzoxazole may engage in with its host protein. Furthermore, bioavailability, metabolism and the use of benzoxazole as a bioisostere are discussed. The review is extended to cover structure-activity relationship studies of 2-substituted benzoxazoles, 2-substituted oxazolopyridines, and in perspective, application of the recently published novel heterocycle oxazolopyrazine in medicinal chemistry studies.

U2 - 10.1016/j.ejmech.2014.11.064

DO - 10.1016/j.ejmech.2014.11.064

M3 - Journal article

C2 - 25487760

SN - 0223-5234

VL - 97

SP - 778

EP - 785

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Benzoxazoles and oxazolopyridines in medicinal chemistry studies

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater