TY - JOUR
T1 - BCG protects against tuberculosis irrespective of HIV status
T2 - a matched case-control study in Mwanza, Tanzania
AU - Faurholt-Jepsen, Daniel
AU - Range, Nyagosya
AU - PrayGod, George
AU - Jeremiah, Kidola
AU - Faurholt-Jepsen, Maria
AU - Aabye, Martine G
AU - Grewal, Harleen M S
AU - Changalucha, John
AU - Witte, Daniel R
AU - Andersen, Aase B
AU - Friis, Henrik
N1 - CURIS 2013 NEXS 044
PY - 2013/3
Y1 - 2013/3
N2 - While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.
AB - While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.
U2 - 10.1136/thoraxjnl-2012-201971
DO - 10.1136/thoraxjnl-2012-201971
M3 - Letter
C2 - 22923459
SN - 0040-6376
VL - 68
SP - 288
EP - 289
JO - Thorax
JF - Thorax
IS - 3
ER -
