Baseline profiles of adolescent vs. adult-onset first-episode psychosis in an early detection program

I Joa; Jan Olav Johannessen; J Langeveld; Svein Friis; I Melle; S Opjordsmoen; Erik Simonsen; P Vaglum; T McGlashan; T K Larsen

doi:10.1111/j.1600-0447.2008.01338.x

Baseline profiles of adolescent vs. adult-onset first-episode psychosis in an early detection program

I Joa, Jan Olav Johannessen, J Langeveld, Svein Friis, I Melle, S Opjordsmoen, Erik Simonsen, P Vaglum, T McGlashan, T K Larsen

63 Citationer (Scopus)

Abstract

OBJECTIVE: Psychotic disorders often start in adolescence. We aim to investigate premorbid and baseline differences characterizing patients with an onset of psychosis in adolescence versus adulthood.

METHOD: We compare first-episode, DSM-IV non-affective psychosis with onset before (n = 43) and after (n = 189) 18 years on duration of untreated psychosis (DUP), level of symptoms, suicidal behaviour, and other baseline clinical and demographic characteristics.

RESULTS: Adolescent onset patients had poorer premorbid functioning, a longer DUP, higher suicidality, and more depressive symptoms. They also had better cognition, fewer psychotic symptoms, and were more likely to be treated on an out-patient basis.

CONCLUSION: Adolescents with first-episode psychosis may have a slower and more silent, i.e. insidious onset, and are at risk of experiencing longer treatment delays than adults. They fit the description of what used to be labeled process (versus reactive) schizophrenia.

Originalsprog	Engelsk
Bogserie	Acta Psychiatrica Scandinavica. Supplementum
Vol/bind	119
Udgave nummer	6
Sider (fra-til)	494-500
Antal sider	7
ISSN	0065-1591
DOI	https://doi.org/10.1111/j.1600-0447.2008.01338.x
Status	Udgivet - jun. 2009

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10.1111/j.1600-0447.2008.01338.x

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abstract = "OBJECTIVE: Psychotic disorders often start in adolescence. We aim to investigate premorbid and baseline differences characterizing patients with an onset of psychosis in adolescence versus adulthood.METHOD: We compare first-episode, DSM-IV non-affective psychosis with onset before (n = 43) and after (n = 189) 18 years on duration of untreated psychosis (DUP), level of symptoms, suicidal behaviour, and other baseline clinical and demographic characteristics.RESULTS: Adolescent onset patients had poorer premorbid functioning, a longer DUP, higher suicidality, and more depressive symptoms. They also had better cognition, fewer psychotic symptoms, and were more likely to be treated on an out-patient basis.CONCLUSION: Adolescents with first-episode psychosis may have a slower and more silent, i.e. insidious onset, and are at risk of experiencing longer treatment delays than adults. They fit the description of what used to be labeled process (versus reactive) schizophrenia.",

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AU - Joa, I

AU - Johannessen, Jan Olav

AU - Langeveld, J

AU - Friis, Svein

AU - Melle, I

AU - Opjordsmoen, S

AU - Simonsen, Erik

AU - Vaglum, P

AU - McGlashan, T

AU - Larsen, T K

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N2 - OBJECTIVE: Psychotic disorders often start in adolescence. We aim to investigate premorbid and baseline differences characterizing patients with an onset of psychosis in adolescence versus adulthood.METHOD: We compare first-episode, DSM-IV non-affective psychosis with onset before (n = 43) and after (n = 189) 18 years on duration of untreated psychosis (DUP), level of symptoms, suicidal behaviour, and other baseline clinical and demographic characteristics.RESULTS: Adolescent onset patients had poorer premorbid functioning, a longer DUP, higher suicidality, and more depressive symptoms. They also had better cognition, fewer psychotic symptoms, and were more likely to be treated on an out-patient basis.CONCLUSION: Adolescents with first-episode psychosis may have a slower and more silent, i.e. insidious onset, and are at risk of experiencing longer treatment delays than adults. They fit the description of what used to be labeled process (versus reactive) schizophrenia.

AB - OBJECTIVE: Psychotic disorders often start in adolescence. We aim to investigate premorbid and baseline differences characterizing patients with an onset of psychosis in adolescence versus adulthood.METHOD: We compare first-episode, DSM-IV non-affective psychosis with onset before (n = 43) and after (n = 189) 18 years on duration of untreated psychosis (DUP), level of symptoms, suicidal behaviour, and other baseline clinical and demographic characteristics.RESULTS: Adolescent onset patients had poorer premorbid functioning, a longer DUP, higher suicidality, and more depressive symptoms. They also had better cognition, fewer psychotic symptoms, and were more likely to be treated on an out-patient basis.CONCLUSION: Adolescents with first-episode psychosis may have a slower and more silent, i.e. insidious onset, and are at risk of experiencing longer treatment delays than adults. They fit the description of what used to be labeled process (versus reactive) schizophrenia.

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KW - Male

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KW - Psychiatric Status Rating Scales

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KW - Risk Factors

KW - Schizophrenia

KW - Schizophrenic Psychology

KW - Suicide

KW - Time Factors

KW - Comparative Study

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

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JO - Acta Psychiatrica Scandinavica, Supplement

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Baseline profiles of adolescent vs. adult-onset first-episode psychosis in an early detection program

Abstract

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