TY - JOUR
T1 - Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial
AU - Solomon, Scott D
AU - Rizkala, Adel R
AU - Lefkowitz, Martin P
AU - Shi, Victor C
AU - Gong, JianJian
AU - Anavekar, Nagesh
AU - Anker, Stefan D
AU - Arango, Juan L
AU - Arenas, Jose L
AU - Atar, Dan
AU - Ben-Gal, Turia
AU - Boytsov, Sergey A
AU - Chen, Chen-Huan
AU - Chopra, Vijay K
AU - Cleland, John
AU - Comin-Colet, Josep
AU - Duengen, Hans-Dirk
AU - Echeverría Correa, Luis E
AU - Filippatos, Gerasimos
AU - Flammer, Andreas J
AU - Galinier, Michel
AU - Godoy, Armando
AU - Goncalvesova, Eva
AU - Janssens, Stefan
AU - Katova, Tzvetana
AU - Køber, Lars
AU - Lelonek, Małgorzata
AU - Linssen, Gerard
AU - Lund, Lars H
AU - O'Meara, Eileen
AU - Merkely, Béla
AU - Milicic, Davor
AU - Oh, Byung-Hee
AU - Perrone, Sergio V
AU - Ranjith, Naresh
AU - Saito, Yoshihiko
AU - Saraiva, Jose F
AU - Shah, Sanjiv
AU - Seferovic, Petar M
AU - Senni, Michele
AU - Sibulo, Antonio S
AU - Sim, David
AU - Sweitzer, Nancy K
AU - Taurio, Jyrki
AU - Vinereanu, Dragos
AU - Vrtovec, Bojan
AU - Widimský, Jiří
AU - Yilmaz, Mehmet B
AU - Zhou, Jingmin
AU - Zweiker, Robert
AU - et al.
N1 - © 2018 American Heart Association, Inc.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - BACKGROUND: To describe the baseline characteristics of patients with heart failure and preserved left ventricular ejection fraction enrolled in the PARAGON-HF trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Global Outcomes in HFpEF) comparing sacubitril/valsartan to valsartan in reducing morbidity and mortality.METHODS AND RESULTS: We report key demographic, clinical, and laboratory findings, and baseline therapies, of 4822 patients randomized in PARAGON-HF, grouped by factors that influence criteria for study inclusion. We further compared baseline characteristics of patients enrolled in PARAGON-HF with those patients enrolled in other recent trials of heart failure with preserved ejection fraction (HFpEF). Among patients enrolled from various regions (16% Asia-Pacific, 37% Central Europe, 7% Latin America, 12% North America, 28% Western Europe), the mean age of patients enrolled in PARAGON-HF was 72.7±8.4 years, 52% of patients were female, and mean left ventricular ejection fraction was 57.5%, similar to other trials of HFpEF. Most patients were in New York Heart Association class II, and 38% had ≥1 hospitalizations for heart failure within the previous 9 months. Diabetes mellitus (43%) and chronic kidney disease (47%) were more prevalent than in previous trials of HFpEF. Many patients were prescribed angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (85%), β-blockers (80%), calcium channel blockers (36%), and mineralocorticoid receptor antagonists (24%). As specified in the protocol, virtually all patients were on diuretics, had elevated plasma concentrations of N-terminal pro-B-type natriuretic peptide (median, 911 pg/mL; interquartile range, 464-1610), and structural heart disease.CONCLUSIONS: PARAGON-HF represents a contemporary group of patients with HFpEF with similar age and sex distribution compared with prior HFpEF trials but higher prevalence of comorbidities. These findings provide insights into the impact of inclusion criteria on, and regional variation in, HFpEF patient characteristics.CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01920711.
AB - BACKGROUND: To describe the baseline characteristics of patients with heart failure and preserved left ventricular ejection fraction enrolled in the PARAGON-HF trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Global Outcomes in HFpEF) comparing sacubitril/valsartan to valsartan in reducing morbidity and mortality.METHODS AND RESULTS: We report key demographic, clinical, and laboratory findings, and baseline therapies, of 4822 patients randomized in PARAGON-HF, grouped by factors that influence criteria for study inclusion. We further compared baseline characteristics of patients enrolled in PARAGON-HF with those patients enrolled in other recent trials of heart failure with preserved ejection fraction (HFpEF). Among patients enrolled from various regions (16% Asia-Pacific, 37% Central Europe, 7% Latin America, 12% North America, 28% Western Europe), the mean age of patients enrolled in PARAGON-HF was 72.7±8.4 years, 52% of patients were female, and mean left ventricular ejection fraction was 57.5%, similar to other trials of HFpEF. Most patients were in New York Heart Association class II, and 38% had ≥1 hospitalizations for heart failure within the previous 9 months. Diabetes mellitus (43%) and chronic kidney disease (47%) were more prevalent than in previous trials of HFpEF. Many patients were prescribed angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (85%), β-blockers (80%), calcium channel blockers (36%), and mineralocorticoid receptor antagonists (24%). As specified in the protocol, virtually all patients were on diuretics, had elevated plasma concentrations of N-terminal pro-B-type natriuretic peptide (median, 911 pg/mL; interquartile range, 464-1610), and structural heart disease.CONCLUSIONS: PARAGON-HF represents a contemporary group of patients with HFpEF with similar age and sex distribution compared with prior HFpEF trials but higher prevalence of comorbidities. These findings provide insights into the impact of inclusion criteria on, and regional variation in, HFpEF patient characteristics.CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01920711.
U2 - 10.1161/circheartfailure.118.004962
DO - 10.1161/circheartfailure.118.004962
M3 - Journal article
C2 - 29980595
SN - 1941-3289
VL - 11
SP - 1
EP - 10
JO - Circulation. Heart failure
JF - Circulation. Heart failure
IS - 7
M1 - e004962
ER -
