Basal stamcellebiologi og cancer

Bo T Porse; Ole W Petersen; Kristian Helin

Basal stamcellebiologi og cancer

Bo T Porse, Ole W Petersen, Kristian Helin

Institut for Cellulær og Molekylær Medicin

Abstract

The finding that tumours, like normal tissues, are endowed with varying degrees of cellular heterogeneity has far-reaching consequences for our understanding of cancer. The cancer stem cell and clonal evolution models have both been proposed to explain tumour-associated cellular heterogeneity. Here, we briefly review these two non-exclusive models with special emphasis on how they aid our understanding of cancer and their implications for therapeutic strategies. Finally, we discuss the close association between basic stem cell biology and cancer, focusing on the role of self-renewal.

Bidragets oversatte titel	[Basic stem cell biology and cancer]
Originalsprog	Dansk
Tidsskrift	Ugeskrift for læger
Vol/bind	172
Udgave nummer	38
Sider (fra-til)	2600-3
Antal sider	4
ISSN	0041-5782
Status	Udgivet - 20 sep. 2010

Emneord

Antineoplastic Agents
Drug Discovery
Humans
Models, Biological
Neoplasms
Neoplastic Stem Cells

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Citationsformater

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TY - JOUR

T1 - Basal stamcellebiologi og cancer

AU - Porse, Bo T

AU - Petersen, Ole W

AU - Helin, Kristian

PY - 2010/9/20

Y1 - 2010/9/20

N2 - The finding that tumours, like normal tissues, are endowed with varying degrees of cellular heterogeneity has far-reaching consequences for our understanding of cancer. The cancer stem cell and clonal evolution models have both been proposed to explain tumour-associated cellular heterogeneity. Here, we briefly review these two non-exclusive models with special emphasis on how they aid our understanding of cancer and their implications for therapeutic strategies. Finally, we discuss the close association between basic stem cell biology and cancer, focusing on the role of self-renewal.

AB - The finding that tumours, like normal tissues, are endowed with varying degrees of cellular heterogeneity has far-reaching consequences for our understanding of cancer. The cancer stem cell and clonal evolution models have both been proposed to explain tumour-associated cellular heterogeneity. Here, we briefly review these two non-exclusive models with special emphasis on how they aid our understanding of cancer and their implications for therapeutic strategies. Finally, we discuss the close association between basic stem cell biology and cancer, focusing on the role of self-renewal.

KW - Antineoplastic Agents

KW - Drug Discovery

KW - Humans

KW - Models, Biological

KW - Neoplasms

KW - Neoplastic Stem Cells

M3 - Tidsskriftartikel

C2 - 20920403

SN - 0041-5782

VL - 172

SP - 2600

EP - 2603

JO - Ugeskrift for læger

JF - Ugeskrift for læger

IS - 38

ER -

Basal stamcellebiologi og cancer

Abstract

Emneord

FN’s Verdensmål

Fingeraftryk

Citationsformater