Bacterial mitotic machineries

Kenn Gerdes; Jakob Møller-Jensen; Gitte Ebersbach; Thomas Kruse; Kurt Nordström; Gitte Ebersbach Charbon

Bacterial mitotic machineries

Kenn Gerdes, Jakob Møller-Jensen, Gitte Ebersbach, Thomas Kruse, Kurt Nordström, Gitte Ebersbach Charbon

Microbiology

109 Citationer (Scopus)

Abstract

Here, we review recent progress that yields fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells. In particular, we describe how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division. Thus, the ParM protein of plasmid R1 forms F actin-like filaments that separate and move plasmid DNA from mid-cell to the cell poles. Evidence from three different laboratories indicate that the morphogenetic MreB protein may be involved in segregation of the bacterial chromosome.

Originalsprog	Engelsk
Tidsskrift	Cell
Vol/bind	116
Udgave nummer	3
Sider (fra-til)	359-66
Antal sider	8
ISSN	0092-8674
Status	Udgivet - 6 feb. 2004

Citationsformater

@article{1c929a8fcae64b07b80894429a76103a,

title = "Bacterial mitotic machineries",

abstract = "Here, we review recent progress that yields fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells. In particular, we describe how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division. Thus, the ParM protein of plasmid R1 forms F actin-like filaments that separate and move plasmid DNA from mid-cell to the cell poles. Evidence from three different laboratories indicate that the morphogenetic MreB protein may be involved in segregation of the bacterial chromosome.",

keywords = "Actins, Adenosine Triphosphatases, Bacteria, Chromosome Segregation, Chromosomes, Bacterial, DNA, Bacterial, Escherichia coli Proteins, Microfilaments, Mitosis, R Factors",

author = "Kenn Gerdes and Jakob M{\o}ller-Jensen and Gitte Ebersbach and Thomas Kruse and Kurt Nordstr{\"o}m and Charbon, {Gitte Ebersbach}",

year = "2004",

month = feb,

day = "6",

language = "English",

volume = "116",

pages = "359--66",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Bacterial mitotic machineries

AU - Gerdes, Kenn

AU - Møller-Jensen, Jakob

AU - Ebersbach, Gitte

AU - Kruse, Thomas

AU - Nordström, Kurt

AU - Charbon, Gitte Ebersbach

PY - 2004/2/6

Y1 - 2004/2/6

N2 - Here, we review recent progress that yields fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells. In particular, we describe how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division. Thus, the ParM protein of plasmid R1 forms F actin-like filaments that separate and move plasmid DNA from mid-cell to the cell poles. Evidence from three different laboratories indicate that the morphogenetic MreB protein may be involved in segregation of the bacterial chromosome.

AB - Here, we review recent progress that yields fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells. In particular, we describe how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division. Thus, the ParM protein of plasmid R1 forms F actin-like filaments that separate and move plasmid DNA from mid-cell to the cell poles. Evidence from three different laboratories indicate that the morphogenetic MreB protein may be involved in segregation of the bacterial chromosome.

KW - Actins

KW - Adenosine Triphosphatases

KW - Bacteria

KW - Chromosome Segregation

KW - Chromosomes, Bacterial

KW - DNA, Bacterial

KW - Escherichia coli Proteins

KW - Microfilaments

KW - Mitosis

KW - R Factors

M3 - Journal article

C2 - 15016371

SN - 0092-8674

VL - 116

SP - 359

EP - 366

JO - Cell

JF - Cell

IS - 3

ER -

Bacterial mitotic machineries

Abstract

Fingeraftryk

Citationsformater