Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

Antti Cajanus; Anette Hall; Juha Koikkalainen; Eino Solje; Antti Tolonen; Timo Urhemaa; Yawu Liu; Ramona M Haanpää; Päivi Hartikainen; Seppo Helisalmi; Ville Korhonen; Daniel Rueckert; Steen Hasselbalch; Gunhild Waldemar; Patrizia Mecocci; Ritva Vanninen; Mark van Gils; Hilkka Soininen; Jyrki Lötjönen; Anne M Remes

doi:10.1159/000486849

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

Antti Cajanus, Anette Hall, Juha Koikkalainen, Eino Solje, Antti Tolonen, Timo Urhemaa, Yawu Liu, Ramona M Haanpää, Päivi Hartikainen, Seppo Helisalmi, Ville Korhonen, Daniel Rueckert, Steen Hasselbalch, Gunhild Waldemar, Patrizia Mecocci, Ritva Vanninen, Mark van Gils, Hilkka Soininen, Jyrki Lötjönen, Anne M Remes

Institut for Klinisk Medicin

7 Citationer (Scopus)

33 Downloads (Pure)

Abstract

Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity.

Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities. Each patient was then individually compared to an independent reference group in order to attain diagnostic suggestions.

Results: Only VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the C9ORF72 expansion carriers than noncarriers.

Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.

Originalsprog	Engelsk
Tidsskrift	Dementia and Geriatric Cognitive Disorders Extra
Vol/bind	8
Udgave nummer	1
Sider (fra-til)	51-59
Antal sider	9
ISSN	1664-5464
DOI	https://doi.org/10.1159/000486849
Status	Udgivet - 1 jan. 2018

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10.1159/000486849Licens: CC BY-NC-ND

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia DiagnosisForlagets udgivne version, 1 MBLicens: CC BY-NC-ND

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Cajanus, A., Hall, A., Koikkalainen, J., Solje, E., Tolonen, A., Urhemaa, T., Liu, Y., Haanpää, R. M., Hartikainen, P., Helisalmi, S., Korhonen, V., Rueckert, D., Hasselbalch, S., Waldemar, G., Mecocci, P., Vanninen, R., van Gils, M., Soininen, H., Lötjönen, J., & Remes, A. M. (2018). Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis. Dementia and Geriatric Cognitive Disorders Extra, 8(1), 51-59. https://doi.org/10.1159/000486849

Cajanus, A, Hall, A, Koikkalainen, J, Solje, E, Tolonen, A, Urhemaa, T, Liu, Y, Haanpää, RM, Hartikainen, P, Helisalmi, S, Korhonen, V, Rueckert, D, Hasselbalch, S , Waldemar, G, Mecocci, P, Vanninen, R, van Gils, M, Soininen, H, Lötjönen, J & Remes, AM 2018, 'Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis', Dementia and Geriatric Cognitive Disorders Extra, bind 8, nr. 1, s. 51-59. https://doi.org/10.1159/000486849

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title = "Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis",

abstract = "Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity.Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities. Each patient was then individually compared to an independent reference group in order to attain diagnostic suggestions.Results: Only VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the C9ORF72 expansion carriers than noncarriers.Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.",

author = "Antti Cajanus and Anette Hall and Juha Koikkalainen and Eino Solje and Antti Tolonen and Timo Urhemaa and Yawu Liu and Haanp{\"a}{\"a}, {Ramona M} and P{\"a}ivi Hartikainen and Seppo Helisalmi and Ville Korhonen and Daniel Rueckert and Steen Hasselbalch and Gunhild Waldemar and Patrizia Mecocci and Ritva Vanninen and {van Gils}, Mark and Hilkka Soininen and Jyrki L{\"o}tj{\"o}nen and Remes, {Anne M}",

year = "2018",

month = jan,

day = "1",

doi = "10.1159/000486849",

language = "English",

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pages = "51--59",

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T1 - Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

AU - Cajanus, Antti

AU - Hall, Anette

AU - Koikkalainen, Juha

AU - Solje, Eino

AU - Tolonen, Antti

AU - Urhemaa, Timo

AU - Liu, Yawu

AU - Haanpää, Ramona M

AU - Hartikainen, Päivi

AU - Helisalmi, Seppo

AU - Korhonen, Ville

AU - Rueckert, Daniel

AU - Hasselbalch, Steen

AU - Waldemar, Gunhild

AU - Mecocci, Patrizia

AU - Vanninen, Ritva

AU - van Gils, Mark

AU - Soininen, Hilkka

AU - Lötjönen, Jyrki

AU - Remes, Anne M

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity.Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities. Each patient was then individually compared to an independent reference group in order to attain diagnostic suggestions.Results: Only VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the C9ORF72 expansion carriers than noncarriers.Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.

AB - Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity.Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities. Each patient was then individually compared to an independent reference group in order to attain diagnostic suggestions.Results: Only VBM and VOL showed utility in correctly identifying bvFTD from our set of data. The overall classification sensitivity of bvFTD with VOL + VBM achieved a total sensitivity of 60%. Using VOL + VBM, 32% were misclassified as having LBD. There was a trend of higher values for classification sensitivity of the C9ORF72 expansion carriers than noncarriers.Conclusion: VOL, VBM, and their combination are effective in differential diagnostics between bvFTD and AD or SMC. However, MRI atrophy profiles for bvFTD and LBD are too similar for a reliable differentiation with the quantification methods tested in this study.

U2 - 10.1159/000486849

DO - 10.1159/000486849

M3 - Journal article

C2 - 29606954

SN - 1664-5464

VL - 8

SP - 51

EP - 59

JO - Dementia and Geriatric Cognitive Disorders Extra

JF - Dementia and Geriatric Cognitive Disorders Extra

IS - 1

ER -

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

Abstract

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