Attenuation of beta and gamma oscillations in schizophrenia spectrum patients following hand posture perturbation

TY - JOUR

T1 - Attenuation of beta and gamma oscillations in schizophrenia spectrum patients following hand posture perturbation

AU - Arnfred, Sidse Marie Hemmingsen

AU - Mørup, Morten

AU - Thalbitzer, Jørgen

AU - Jansson, Lennart

AU - Parnas, Josef

AU - Arnfred, Sidse Marie

N1 - Copyright © 2009 Elsevier Ltd. All rights reserved.

PY - 2011/1/30

Y1 - 2011/1/30

N2 - Several electroencephalographic (EEG) studies in schizophrenia report that the patients have reduced evoked gamma activity following visual and auditory stimulation. Somatosensory gamma activity has not previously been examined. It has been suggested that a dysfunction basic to schizophrenia spectrum traits would involve proprioceptive information processing and this has recently been supported by the finding of diminished latency of early proprioceptive evoked potentials in a sample of chronic schizophrenia patients. The proprioceptive stimulus used previously, and presently, consisted of an abrupt increase of weight on a hand-held load. Eighteen first-time admitted schizophrenia spectrum patients and 18 healthy matched comparison subjects were included. Proprioceptive evoked potentials were recorded as 64-channels EEG for 120 trials in two runs differing in sequence. Contra-lateral evoked beta (latency 90. ms, frequency 21. Hz) and gamma (latency 70. ms, frequency 32. Hz) oscillations were attenuated in the patient group. The healthy comparison subjects had increased gamma amplitude in the left hemisphere in the regular sequence, a phenomenon not seen in the patients. The deviant findings were unexpectedly more circumscribed in the schizophrenia than in the schizotypal personality disorder (SPD) patients. Future studies should include several concurrent psychophysiological measures.

AB - Several electroencephalographic (EEG) studies in schizophrenia report that the patients have reduced evoked gamma activity following visual and auditory stimulation. Somatosensory gamma activity has not previously been examined. It has been suggested that a dysfunction basic to schizophrenia spectrum traits would involve proprioceptive information processing and this has recently been supported by the finding of diminished latency of early proprioceptive evoked potentials in a sample of chronic schizophrenia patients. The proprioceptive stimulus used previously, and presently, consisted of an abrupt increase of weight on a hand-held load. Eighteen first-time admitted schizophrenia spectrum patients and 18 healthy matched comparison subjects were included. Proprioceptive evoked potentials were recorded as 64-channels EEG for 120 trials in two runs differing in sequence. Contra-lateral evoked beta (latency 90. ms, frequency 21. Hz) and gamma (latency 70. ms, frequency 32. Hz) oscillations were attenuated in the patient group. The healthy comparison subjects had increased gamma amplitude in the left hemisphere in the regular sequence, a phenomenon not seen in the patients. The deviant findings were unexpectedly more circumscribed in the schizophrenia than in the schizotypal personality disorder (SPD) patients. Future studies should include several concurrent psychophysiological measures.

U2 - 10.1016/j.psychres.2009.10.005

DO - 10.1016/j.psychres.2009.10.005

M3 - Journal article

C2 - 20494456

SN - 0165-1781

VL - 185

SP - 215

EP - 224

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1-2

ER -