TY - JOUR
T1 - Atrial secretion of B-type natriuretic peptide
AU - Goetze, Jens Peter
AU - Friis-Hansen, Lennart
AU - Rehfeld, Jens F
AU - Nilsson, Brian
AU - Svendsen, Jesper Hastrup
N1 - Keywords: Atrial Fibrillation; Heart Atria; Heart Failure; Humans; Microscopy, Confocal; Myocytes, Cardiac; Natriuretic Peptide, Brain
PY - 2006
Y1 - 2006
N2 - In the normal heart, the endocrine capacity resides in the atria. Atrial myocytes express and secrete natriuretic hormones that regulate fluid homeostasis and blood pressure. But in ventricular disease, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression is also activated in ventricular myocytes. Plasma concentrations of natriuretic peptides and their biosynthetic precursors are accordingly increased in patients with marked ventricular dysfunction. In contrast, atrial peptide secretion in ventricular disease has received less attention, and our present understanding of the endocrine atria during ventricular dysfunction is still scarce. Although ventricular disease and increased circulating concentrations are associated, it does not entail that the ventricle is the sole or even the main source in all types of heart disease. Clearly, the endocrine atria are also active in heart failure. Plasma measurement of cardiac natriuretic peptides and their molecular precursors can perhaps help us to discriminate when, where and how.
AB - In the normal heart, the endocrine capacity resides in the atria. Atrial myocytes express and secrete natriuretic hormones that regulate fluid homeostasis and blood pressure. But in ventricular disease, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression is also activated in ventricular myocytes. Plasma concentrations of natriuretic peptides and their biosynthetic precursors are accordingly increased in patients with marked ventricular dysfunction. In contrast, atrial peptide secretion in ventricular disease has received less attention, and our present understanding of the endocrine atria during ventricular dysfunction is still scarce. Although ventricular disease and increased circulating concentrations are associated, it does not entail that the ventricle is the sole or even the main source in all types of heart disease. Clearly, the endocrine atria are also active in heart failure. Plasma measurement of cardiac natriuretic peptides and their molecular precursors can perhaps help us to discriminate when, where and how.
U2 - 10.1093/eurheartj/ehl109
DO - 10.1093/eurheartj/ehl109
M3 - Journal article
C2 - 16785247
SN - 0195-668X
VL - 27
SP - 1648
EP - 1650
JO - European Heart Journal
JF - European Heart Journal
IS - 14
ER -