@article{429d1710b31511debc73000ea68e967b,
title = "Atrial natriuretic peptide augments the blood-brain transfer of water but not leucine and glucose.",
abstract = "Recent evidence predicts an effect of atrial natriuretic peptide (ANP) on the blood-brain transfer of water. To test this prediction, we measured the blood-brain transfer of water, L-leucine, and D-glucose in 9 brain regions of male rats after intravenous injection of 10 pmol ANP. The peptide elicited an increase of the permeability-surface area (PaS) product of labeled water by 28-108% while the PaS products of leucine and glucose remained unchanged. Cerebral blood flow increased 15-48% while cardiac output and plasma volume in brain did not alter, indicating no change of capillary surface area (CSA). Regionally, the CSA varied from 63 cm2/g (striatum) to 97 cm2/g (colliculi) and the fraction of capillaries contributing to the total vascular volume varied from 29% (olfactory bulb/lobe) to 62% (striatum). The blood-brain barrier (BBB) permeability to water (5.7 micron/s) was an order of magnitude higher than to glucose (0.4 micron/s) or to leucine (0.3 micron/s).",
author = "P Brust and A Baethmann and A Gjedde and A Ermisch",
year = "1991",
language = "English",
volume = "564",
pages = "91--6",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",
}