Atopic diseases in twins born after assisted reproduction

Ida Jäderberg; Simon F Thomsen; Kirsten Ohm Kyvik; Axel Skytthe; Vibeke Backer

doi:10.1111/j.1365-3016.2011.01246.x

Atopic diseases in twins born after assisted reproduction

Ida Jäderberg, Simon F Thomsen, Kirsten Ohm Kyvik, Axel Skytthe, Vibeke Backer

6 Citationer (Scopus)

Abstract

We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0.773 respectively) compared with children born after spontaneous conception. Assisted reproduction did not modify the heritability of atopic diseases. This study does not support an association between assisted reproduction and development of atopic diseases. This result must be confirmed in subsequent studies, preferably of singleton populations.

Originalsprog	Engelsk
Tidsskrift	Paediatric and Perinatal Epidemiology (Print)
Vol/bind	26
Udgave nummer	2
Sider (fra-til)	140-5
Antal sider	6
ISSN	0269-5022
DOI	https://doi.org/10.1111/j.1365-3016.2011.01246.x
Status	Udgivet - mar. 2012

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10.1111/j.1365-3016.2011.01246.x

Citationsformater

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title = "Atopic diseases in twins born after assisted reproduction",

abstract = "We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0.773 respectively) compared with children born after spontaneous conception. Assisted reproduction did not modify the heritability of atopic diseases. This study does not support an association between assisted reproduction and development of atopic diseases. This result must be confirmed in subsequent studies, preferably of singleton populations.",

author = "Ida J{\"a}derberg and Thomsen, {Simon F} and Kyvik, {Kirsten Ohm} and Axel Skytthe and Vibeke Backer",

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T1 - Atopic diseases in twins born after assisted reproduction

AU - Jäderberg, Ida

AU - Thomsen, Simon F

AU - Kyvik, Kirsten Ohm

AU - Skytthe, Axel

AU - Backer, Vibeke

PY - 2012/3

Y1 - 2012/3

N2 - We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0.773 respectively) compared with children born after spontaneous conception. Assisted reproduction did not modify the heritability of atopic diseases. This study does not support an association between assisted reproduction and development of atopic diseases. This result must be confirmed in subsequent studies, preferably of singleton populations.

AB - We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0.773 respectively) compared with children born after spontaneous conception. Assisted reproduction did not modify the heritability of atopic diseases. This study does not support an association between assisted reproduction and development of atopic diseases. This result must be confirmed in subsequent studies, preferably of singleton populations.

U2 - 10.1111/j.1365-3016.2011.01246.x

DO - 10.1111/j.1365-3016.2011.01246.x

M3 - Journal article

C2 - 22324500

SN - 0269-5022

VL - 26

SP - 140

EP - 145

JO - Paediatric and Perinatal Epidemiology

JF - Paediatric and Perinatal Epidemiology

IS - 2

ER -

Atopic diseases in twins born after assisted reproduction

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