Astrocytes in chronic pain and itch

Ru-Rong Ji; Christopher R. Donnelly; Maiken Nedergaard

doi:10.1038/s41583-019-0218-1

Astrocytes in chronic pain and itch

Ru-Rong Ji, Christopher R. Donnelly, Maiken Nedergaard

48 Citationer (Scopus)

Abstract

Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte ‘gliopathy’. Indeed, in recent years there has been substantial progress in our understanding of how astrocytes can regulate nociceptive synaptic transmission via neuronal–glial and glial–glial cell interactions, as well as the involvement of spinal and supraspinal astrocytes in the modulation of pain signalling and the maintenance of neuropathic pain. A role of astrocytes in the pathogenesis of chronic itch is also emerging. These developments suggest that targeting the specific pathways that are responsible for astrogliopathy may represent a novel approach to develop therapies for chronic pain and chronic itch.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews Neuroscience
Vol/bind	20
Udgave nummer	11
Sider (fra-til)	667-685
Antal sider	19
ISSN	1471-003X
DOI	https://doi.org/10.1038/s41583-019-0218-1
Status	Udgivet - 1 nov. 2019

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10.1038/s41583-019-0218-1

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title = "Astrocytes in chronic pain and itch",

abstract = "Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte {\textquoteleft}gliopathy{\textquoteright}. Indeed, in recent years there has been substantial progress in our understanding of how astrocytes can regulate nociceptive synaptic transmission via neuronal–glial and glial–glial cell interactions, as well as the involvement of spinal and supraspinal astrocytes in the modulation of pain signalling and the maintenance of neuropathic pain. A role of astrocytes in the pathogenesis of chronic itch is also emerging. These developments suggest that targeting the specific pathways that are responsible for astrogliopathy may represent a novel approach to develop therapies for chronic pain and chronic itch.",

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T1 - Astrocytes in chronic pain and itch

AU - Ji, Ru-Rong

AU - Donnelly, Christopher R.

AU - Nedergaard, Maiken

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N2 - Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte ‘gliopathy’. Indeed, in recent years there has been substantial progress in our understanding of how astrocytes can regulate nociceptive synaptic transmission via neuronal–glial and glial–glial cell interactions, as well as the involvement of spinal and supraspinal astrocytes in the modulation of pain signalling and the maintenance of neuropathic pain. A role of astrocytes in the pathogenesis of chronic itch is also emerging. These developments suggest that targeting the specific pathways that are responsible for astrogliopathy may represent a novel approach to develop therapies for chronic pain and chronic itch.

AB - Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte ‘gliopathy’. Indeed, in recent years there has been substantial progress in our understanding of how astrocytes can regulate nociceptive synaptic transmission via neuronal–glial and glial–glial cell interactions, as well as the involvement of spinal and supraspinal astrocytes in the modulation of pain signalling and the maintenance of neuropathic pain. A role of astrocytes in the pathogenesis of chronic itch is also emerging. These developments suggest that targeting the specific pathways that are responsible for astrogliopathy may represent a novel approach to develop therapies for chronic pain and chronic itch.

U2 - 10.1038/s41583-019-0218-1

DO - 10.1038/s41583-019-0218-1

M3 - Review

C2 - 31537912

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VL - 20

SP - 667

EP - 685

JO - Nature Reviews. Neuroscience

JF - Nature Reviews. Neuroscience

IS - 11

ER -

Astrocytes in chronic pain and itch

Abstract

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