Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study

Michelle Dalgas Schmiegelow; Charlotte Andersson; Lars Køber; Søren Skøtt Andersen; Mette Lykke Norgaard; Thomas Bo Jensen; Gunnar Gislason; Siv Mari Berger; Christian Torp-Pedersen

doi:10.1161/JAHA.113.000672

Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study

Michelle Dalgas Schmiegelow, Charlotte Andersson, Lars Køber, Søren Skøtt Andersen, Mette Lykke Norgaard, Thomas Bo Jensen, Gunnar Gislason, Siv Mari Berger, Christian Torp-Pedersen

Institut for Klinisk Medicin

15 Citationer (Scopus)

31 Downloads (Pure)

Abstract

Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. Women giving birth during the years 2004-2009, with no history of cardiovascular disease, renal insufficiency, pregnancy-associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese-I (BMI=30 to <35 kg/m(2)), obese-II (BMI=35 to <40 kg/m(2)), and obese-III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow-up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade-I, 7.17 (CI=6.10 to 8.48) for obese grade-II, and 6.93 (CI=5.47 to 8.79) for obese grade-III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). In this nationwide study of fertile, apparently healthy women, pre-pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth.

Originalsprog	Engelsk
Artikelnummer	e000672
Tidsskrift	American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease
Vol/bind	3
Udgave nummer	2
Sider (fra-til)	1-11
Antal sider	11
ISSN	2047-9980
DOI	https://doi.org/10.1161/JAHA.113.000672
Status	Udgivet - 2014

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1161/JAHA.113.000672Licens: CC BY-NC

e000672.fullForlagets udgivne version, 868 KBLicens: CC BY-NC

Citationsformater

Schmiegelow, M. D., Andersson, C., Køber, L., Andersen, S. S., Norgaard, M. L., Jensen, T. B., Gislason, G., Berger, S. M., & Torp-Pedersen, C. (2014). Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study. American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, 3(2), 1-11. [e000672]. https://doi.org/10.1161/JAHA.113.000672

Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study. / Schmiegelow, Michelle Dalgas; Andersson, Charlotte; Køber, Lars et al.

I: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Bind 3, Nr. 2, e000672, 2014, s. 1-11.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Schmiegelow, MD, Andersson, C, Køber, L, Andersen, SS, Norgaard, ML, Jensen, TB, Gislason, G, Berger, SM & Torp-Pedersen, C 2014, 'Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study', American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, bind 3, nr. 2, e000672, s. 1-11. https://doi.org/10.1161/JAHA.113.000672

@article{5e016f0a8bd14a2cbaf39e442a7366da,

title = "Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study",

abstract = "Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. Women giving birth during the years 2004-2009, with no history of cardiovascular disease, renal insufficiency, pregnancy-associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese-I (BMI=30 to <35 kg/m(2)), obese-II (BMI=35 to <40 kg/m(2)), and obese-III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow-up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade-I, 7.17 (CI=6.10 to 8.48) for obese grade-II, and 6.93 (CI=5.47 to 8.79) for obese grade-III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). In this nationwide study of fertile, apparently healthy women, pre-pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth.",

keywords = "Adult, Age Factors, Body Mass Index, Denmark, Diabetes Mellitus, Dyslipidemias, Female, Fertility, Health Surveys, Humans, Hypertension, Incidence, Kaplan-Meier Estimate, Multivariate Analysis, Obesity, Odds Ratio, Parity, Pregnancy, Prognosis, Risk Assessment, Risk Factors, Sex Factors, Time Factors",

author = "Schmiegelow, {Michelle Dalgas} and Charlotte Andersson and Lars K{\o}ber and Andersen, {S{\o}ren Sk{\o}tt} and Norgaard, {Mette Lykke} and Jensen, {Thomas Bo} and Gunnar Gislason and Berger, {Siv Mari} and Christian Torp-Pedersen",

year = "2014",

doi = "10.1161/JAHA.113.000672",

language = "English",

volume = "3",

pages = "1--11",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study

AU - Schmiegelow, Michelle Dalgas

AU - Andersson, Charlotte

AU - Køber, Lars

AU - Andersen, Søren Skøtt

AU - Norgaard, Mette Lykke

AU - Jensen, Thomas Bo

AU - Gislason, Gunnar

AU - Berger, Siv Mari

AU - Torp-Pedersen, Christian

PY - 2014

Y1 - 2014

N2 - Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. Women giving birth during the years 2004-2009, with no history of cardiovascular disease, renal insufficiency, pregnancy-associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese-I (BMI=30 to <35 kg/m(2)), obese-II (BMI=35 to <40 kg/m(2)), and obese-III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow-up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade-I, 7.17 (CI=6.10 to 8.48) for obese grade-II, and 6.93 (CI=5.47 to 8.79) for obese grade-III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). In this nationwide study of fertile, apparently healthy women, pre-pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth.

AB - Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. Women giving birth during the years 2004-2009, with no history of cardiovascular disease, renal insufficiency, pregnancy-associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese-I (BMI=30 to <35 kg/m(2)), obese-II (BMI=35 to <40 kg/m(2)), and obese-III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow-up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade-I, 7.17 (CI=6.10 to 8.48) for obese grade-II, and 6.93 (CI=5.47 to 8.79) for obese grade-III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). In this nationwide study of fertile, apparently healthy women, pre-pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth.

KW - Adult

KW - Age Factors

KW - Body Mass Index

KW - Denmark

KW - Diabetes Mellitus

KW - Dyslipidemias

KW - Female

KW - Fertility

KW - Health Surveys

KW - Humans

KW - Hypertension

KW - Incidence

KW - Kaplan-Meier Estimate

KW - Multivariate Analysis

KW - Obesity

KW - Odds Ratio

KW - Parity

KW - Pregnancy

KW - Prognosis

KW - Risk Assessment

KW - Risk Factors

KW - Sex Factors

KW - Time Factors

U2 - 10.1161/JAHA.113.000672

DO - 10.1161/JAHA.113.000672

M3 - Journal article

C2 - 24721798

SN - 2047-9980

VL - 3

SP - 1

EP - 11

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 2

M1 - e000672

ER -

Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women—A Nationwide Cohort Study

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater