Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients

TY - JOUR

T1 - Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients

AU - Henningsen, Kristoffer M A

AU - Olesen, Morten S

AU - Haunsoe, Stig

AU - Svendsen, Jesper H

PY - 2011/12

Y1 - 2011/12

N2 - OBJECTIVE: Genome wide association studies have shown an association between rs2200733 at 4q25 and atrial fibrillation (AF). In this case-control study we investigate the association of rs2200733 and lone AF in young patients.METHODS: We included 196 young patients with lone AF and the first episode before the age of 40 years. We analyzed the single nucleotide polymorphism (SNP) rs2200733 for the lone AF patients and compared them to a control group of 176 age matched healthy individuals.RESULTS: No significant differences, in neither genotype distribution, nor minor allele frequencies were found between the lone AF patients and the healthy controls.CONCLUSION: Our results suggest that the rs220733 is not a risk factor for AF in patients with no other cardiovascular disease and with early onset of the arrhythmia.

AB - OBJECTIVE: Genome wide association studies have shown an association between rs2200733 at 4q25 and atrial fibrillation (AF). In this case-control study we investigate the association of rs2200733 and lone AF in young patients.METHODS: We included 196 young patients with lone AF and the first episode before the age of 40 years. We analyzed the single nucleotide polymorphism (SNP) rs2200733 for the lone AF patients and compared them to a control group of 176 age matched healthy individuals.RESULTS: No significant differences, in neither genotype distribution, nor minor allele frequencies were found between the lone AF patients and the healthy controls.CONCLUSION: Our results suggest that the rs220733 is not a risk factor for AF in patients with no other cardiovascular disease and with early onset of the arrhythmia.

KW - Adult

KW - Age of Onset

KW - Atrial Fibrillation/diagnosis

KW - Case-Control Studies

KW - Chi-Square Distribution

KW - Chromosomes, Human, Pair 4

KW - Denmark/epidemiology

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Logistic Models

KW - Odds Ratio

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Risk Assessment

KW - Risk Factors

U2 - 10.3109/14017431.2011.594081

DO - 10.3109/14017431.2011.594081

M3 - Journal article

C2 - 21793630

SN - 1401-7431

VL - 45

SP - 324

EP - 326

JO - Scandinavian Cardiovascular Journal

JF - Scandinavian Cardiovascular Journal

IS - 6

ER -