TY - JOUR
T1 - Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults
T2 - A systematic review and meta-analysis
AU - Rønnstad, Amalie Thorsti Møller
AU - Halling-Overgaard, Anne-Sofie
AU - Hamann, Carsten R
AU - Skov, Lone
AU - Egeberg, Alexander
AU - Thyssen, Jacob P.
PY - 2018/9
Y1 - 2018/9
N2 - BACKGROUND: Atopic dermatitis (AD) has been associated with anxiety and depression, but the magnitude of the alleged association is unknown.OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD in children and adults and, respectively, depression, anxiety, and suicidal behavior.METHODS: The medical databases PubMed, Embase, and PsychINFO were searched.RESULTS: There was a significant association between adult AD and, respectively, depression (pooled odds ratio [OR], 2.19; 95% confidence interval [CI], 1.87-2.57) and anxiety (pooled OR, 2.19; 95% CI, 1.75-2.73). AD was also associated with depression in children (pooled OR, 1.27; 95% CI, 1.12-1.45); few data were available for anxiety. A positive association was found between AD in adults and adolescents and suicidal ideation (pooled OR, 4.32; 95% CI, 1.93-9.66). Only a few studies examined the risk of completed suicide, but the majority showed a positive association between completed suicide and AD.LIMITATIONS: Included studies used different definitions of depression and anxiety, and few studies examined the severity of AD.CONCLUSION: Depression, anxiety, and suicidal ideation should be considered by doctors when treating patients with AD. Because AD disease improvement appears to reduce these risks, this should be a priority.
AB - BACKGROUND: Atopic dermatitis (AD) has been associated with anxiety and depression, but the magnitude of the alleged association is unknown.OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD in children and adults and, respectively, depression, anxiety, and suicidal behavior.METHODS: The medical databases PubMed, Embase, and PsychINFO were searched.RESULTS: There was a significant association between adult AD and, respectively, depression (pooled odds ratio [OR], 2.19; 95% confidence interval [CI], 1.87-2.57) and anxiety (pooled OR, 2.19; 95% CI, 1.75-2.73). AD was also associated with depression in children (pooled OR, 1.27; 95% CI, 1.12-1.45); few data were available for anxiety. A positive association was found between AD in adults and adolescents and suicidal ideation (pooled OR, 4.32; 95% CI, 1.93-9.66). Only a few studies examined the risk of completed suicide, but the majority showed a positive association between completed suicide and AD.LIMITATIONS: Included studies used different definitions of depression and anxiety, and few studies examined the severity of AD.CONCLUSION: Depression, anxiety, and suicidal ideation should be considered by doctors when treating patients with AD. Because AD disease improvement appears to reduce these risks, this should be a priority.
KW - Adult
KW - Anxiety/epidemiology
KW - Child
KW - Comorbidity
KW - Depression/epidemiology
KW - Dermatitis, Atopic/epidemiology
KW - Humans
KW - Odds Ratio
KW - Suicidal Ideation
KW - Suicide, Attempted
U2 - 10.1016/j.jaad.2018.03.017
DO - 10.1016/j.jaad.2018.03.017
M3 - Journal article
C2 - 30119868
SN - 0190-9622
VL - 79
SP - 448-456.e30
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -
