Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study

Honglin Song; Susan J Ramus; Susanne Krüger Kjaer; Richard A DiCioccio; Georgia Chenevix-Trench; Celeste Leigh Pearce; Estrid Hogdall; Alice S Whittemore; Valerie McGuire; Claus Hogdall; Jan Blaakaer; Anna H Wu; David J Van Den Berg; Daniel O Stram; Usha Menon; Aleksandra Gentry-Maharaj; Ian J Jacobs; Penny M Webb; Jonathan Beesley; Xiaoqing Chen; Australian Cancer (Ovarian) Study; Australian Ovarian Cancer Study Group; Mary Anne Rossing; Jennifer A Doherty; Jenny Chang-Claude; Shan Wang-Gohrke; Marc T Goodman; Galina Lurie; Pamela J Thompson; Michael E Carney; Roberta B Ness; Kirsten Moysich; Ellen L Goode; Robert A Vierkant; Julie M Cunningham; Stephanie Anderson; Joellen M Schildkraut; Andrew Berchuck; Edwin S Iversen; Patricia G Moorman; Montserrat Garcia-Closas; Stephen Chanock; Jolanta Lissowska; Louise Brinton; Hoda Anton-Culver; Argyrios Ziogas; Wendy R Brewster; Bruce A J Ponder; Douglas F Easton; Simon A Gayther; Paul D P Pharoah; Ovarian Cancer Association Consortium (OCAC)

doi:10.1093/hmg/ddp138

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study

Honglin Song, Susan J Ramus, Susanne Krüger Kjaer, Richard A DiCioccio, Georgia Chenevix-Trench, Celeste Leigh Pearce, Estrid Hogdall, Alice S Whittemore, Valerie McGuire, Claus Hogdall, Jan Blaakaer, Anna H Wu, David J Van Den Berg, Daniel O Stram, Usha Menon, Aleksandra Gentry-Maharaj, Ian J Jacobs, Penny M Webb, Jonathan Beesley, Xiaoqing ChenAustralian Cancer (Ovarian) Study, Australian Ovarian Cancer Study Group, Mary Anne Rossing, Jennifer A Doherty, Jenny Chang-Claude, Shan Wang-Gohrke, Marc T Goodman, Galina Lurie, Pamela J Thompson, Michael E Carney, Roberta B Ness, Kirsten Moysich, Ellen L Goode, Robert A Vierkant, Julie M Cunningham, Stephanie Anderson, Joellen M Schildkraut, Andrew Berchuck, Edwin S Iversen, Patricia G Moorman, Montserrat Garcia-Closas, Stephen Chanock, Jolanta Lissowska, Louise Brinton, Hoda Anton-Culver, Argyrios Ziogas, Wendy R Brewster, Bruce A J Ponder, Douglas F Easton, Simon A Gayther, Paul D P Pharoah, Ovarian Cancer Association Consortium (OCAC)

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Abstract

Udgivelsesdato: 2009-Jun-15

Originalsprog	Engelsk
Tidsskrift	Human Molecular Genetics
Vol/bind	18
Udgave nummer	12
Sider (fra-til)	2297-304
Antal sider	7
ISSN	0964-6906
DOI	https://doi.org/10.1093/hmg/ddp138
Status	Udgivet - 2009

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Song, H., Ramus, S. J., Kjaer, S. K., DiCioccio, R. A., Chenevix-Trench, G., Pearce, C. L., Hogdall, E., Whittemore, A. S., McGuire, V., Hogdall, C., Blaakaer, J., Wu, A. H., Van Den Berg, D. J., Stram, D. O., Menon, U., Gentry-Maharaj, A., Jacobs, I. J., Webb, P. M., Beesley, J., ... Ovarian Cancer Association Consortium (OCAC) (2009). Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. Human Molecular Genetics, 18(12), 2297-304. https://doi.org/10.1093/hmg/ddp138

Song, H, Ramus, SJ, Kjaer, SK, DiCioccio, RA, Chenevix-Trench, G, Pearce, CL, Hogdall, E, Whittemore, AS, McGuire, V, Hogdall, C, Blaakaer, J, Wu, AH, Van Den Berg, DJ, Stram, DO, Menon, U, Gentry-Maharaj, A, Jacobs, IJ, Webb, PM, Beesley, J, Chen, X, Australian Cancer (Ovarian) Study, Australian Ovarian Cancer Study Group, Rossing, MA, Doherty, JA, Chang-Claude, J, Wang-Gohrke, S, Goodman, MT, Lurie, G, Thompson, PJ, Carney, ME, Ness, RB, Moysich, K, Goode, EL, Vierkant, RA, Cunningham, JM, Anderson, S, Schildkraut, JM, Berchuck, A, Iversen, ES, Moorman, PG, Garcia-Closas, M, Chanock, S, Lissowska, J, Brinton, L, Anton-Culver, H, Ziogas, A, Brewster, WR, Ponder, BAJ, Easton, DF, Gayther, SA, Pharoah, PDP & Ovarian Cancer Association Consortium (OCAC) 2009, 'Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study', Human Molecular Genetics, bind 18, nr. 12, s. 2297-304. https://doi.org/10.1093/hmg/ddp138

@article{f4e4dde068a011df928f000ea68e967b,

title = "Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study",

abstract = "Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasive ovarian cancer. Eleven SNPs were initially genotyped in 2927 invasive ovarian cancer cases and 4143 controls from six ovarian cancer case-control studies. Genotype frequencies in cases and controls were compared using a likelihood ratio test in a logistic regression model stratified by study. Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ovarian cancer in non-Hispanic white subjects (P-trend < 0.1). These four SNPs were then genotyped in an additional 4060 cases and 6308 controls from eight independent studies. Only rs4954956 was significantly associated with ovarian cancer risk both in the replication study and in combined analyses. This association was stronger for the serous histological subtype [per minor allele odds ratio (OR) 1.07 95% CI 1.01-1.13, P-trend = 0.02 for all types of ovarian cancer and OR 1.14 95% CI 1.07-1.22, P-trend = 0.00017 for serous ovarian cancer]. In conclusion, we found that rs4954956 was associated with increased ovarian cancer risk, particularly for serous ovarian cancer. However, none of the six confirmed breast cancer susceptibility variants we tested was associated with ovarian cancer risk. Further work will be needed to identify the causal variant associated with rs4954956 or elucidate its function.",

author = "Honglin Song and Ramus, {Susan J} and Kjaer, {Susanne Kr{\"u}ger} and DiCioccio, {Richard A} and Georgia Chenevix-Trench and Pearce, {Celeste Leigh} and Estrid Hogdall and Whittemore, {Alice S} and Valerie McGuire and Claus Hogdall and Jan Blaakaer and Wu, {Anna H} and {Van Den Berg}, {David J} and Stram, {Daniel O} and Usha Menon and Aleksandra Gentry-Maharaj and Jacobs, {Ian J} and Webb, {Penny M} and Jonathan Beesley and Xiaoqing Chen and {Australian Cancer (Ovarian) Study} and {Australian Ovarian Cancer Study Group} and Rossing, {Mary Anne} and Doherty, {Jennifer A} and Jenny Chang-Claude and Shan Wang-Gohrke and Goodman, {Marc T} and Galina Lurie and Thompson, {Pamela J} and Carney, {Michael E} and Ness, {Roberta B} and Kirsten Moysich and Goode, {Ellen L} and Vierkant, {Robert A} and Cunningham, {Julie M} and Stephanie Anderson and Schildkraut, {Joellen M} and Andrew Berchuck and Iversen, {Edwin S} and Moorman, {Patricia G} and Montserrat Garcia-Closas and Stephen Chanock and Jolanta Lissowska and Louise Brinton and Hoda Anton-Culver and Argyrios Ziogas and Brewster, {Wendy R} and Ponder, {Bruce A J} and Easton, {Douglas F} and Gayther, {Simon A} and Pharoah, {Paul D P} and {Ovarian Cancer Association Consortium (OCAC)}",

note = "Keywords: Breast Neoplasms; Case-Control Studies; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Glycoproteins; Humans; Neuropeptides; Ovarian Neoplasms; Polymorphism, Single Nucleotide; Risk Factors",

year = "2009",

doi = "10.1093/hmg/ddp138",

language = "English",

volume = "18",

pages = "2297--304",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study

AU - Song, Honglin

AU - Ramus, Susan J

AU - Kjaer, Susanne Krüger

AU - DiCioccio, Richard A

AU - Chenevix-Trench, Georgia

AU - Pearce, Celeste Leigh

AU - Hogdall, Estrid

AU - Whittemore, Alice S

AU - McGuire, Valerie

AU - Hogdall, Claus

AU - Blaakaer, Jan

AU - Wu, Anna H

AU - Van Den Berg, David J

AU - Stram, Daniel O

AU - Menon, Usha

AU - Gentry-Maharaj, Aleksandra

AU - Jacobs, Ian J

AU - Webb, Penny M

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - Australian Cancer (Ovarian) Study

AU - Australian Ovarian Cancer Study Group

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A

AU - Chang-Claude, Jenny

AU - Wang-Gohrke, Shan

AU - Goodman, Marc T

AU - Lurie, Galina

AU - Thompson, Pamela J

AU - Carney, Michael E

AU - Ness, Roberta B

AU - Moysich, Kirsten

AU - Goode, Ellen L

AU - Vierkant, Robert A

AU - Cunningham, Julie M

AU - Anderson, Stephanie

AU - Schildkraut, Joellen M

AU - Berchuck, Andrew

AU - Iversen, Edwin S

AU - Moorman, Patricia G

AU - Garcia-Closas, Montserrat

AU - Chanock, Stephen

AU - Lissowska, Jolanta

AU - Brinton, Louise

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Brewster, Wendy R

AU - Ponder, Bruce A J

AU - Easton, Douglas F

AU - Gayther, Simon A

AU - Pharoah, Paul D P

AU - Ovarian Cancer Association Consortium (OCAC)

N1 - Keywords: Breast Neoplasms; Case-Control Studies; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Glycoproteins; Humans; Neuropeptides; Ovarian Neoplasms; Polymorphism, Single Nucleotide; Risk Factors

PY - 2009

Y1 - 2009

N2 - Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasive ovarian cancer. Eleven SNPs were initially genotyped in 2927 invasive ovarian cancer cases and 4143 controls from six ovarian cancer case-control studies. Genotype frequencies in cases and controls were compared using a likelihood ratio test in a logistic regression model stratified by study. Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ovarian cancer in non-Hispanic white subjects (P-trend < 0.1). These four SNPs were then genotyped in an additional 4060 cases and 6308 controls from eight independent studies. Only rs4954956 was significantly associated with ovarian cancer risk both in the replication study and in combined analyses. This association was stronger for the serous histological subtype [per minor allele odds ratio (OR) 1.07 95% CI 1.01-1.13, P-trend = 0.02 for all types of ovarian cancer and OR 1.14 95% CI 1.07-1.22, P-trend = 0.00017 for serous ovarian cancer]. In conclusion, we found that rs4954956 was associated with increased ovarian cancer risk, particularly for serous ovarian cancer. However, none of the six confirmed breast cancer susceptibility variants we tested was associated with ovarian cancer risk. Further work will be needed to identify the causal variant associated with rs4954956 or elucidate its function.

AB - Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasive ovarian cancer. Eleven SNPs were initially genotyped in 2927 invasive ovarian cancer cases and 4143 controls from six ovarian cancer case-control studies. Genotype frequencies in cases and controls were compared using a likelihood ratio test in a logistic regression model stratified by study. Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ovarian cancer in non-Hispanic white subjects (P-trend < 0.1). These four SNPs were then genotyped in an additional 4060 cases and 6308 controls from eight independent studies. Only rs4954956 was significantly associated with ovarian cancer risk both in the replication study and in combined analyses. This association was stronger for the serous histological subtype [per minor allele odds ratio (OR) 1.07 95% CI 1.01-1.13, P-trend = 0.02 for all types of ovarian cancer and OR 1.14 95% CI 1.07-1.22, P-trend = 0.00017 for serous ovarian cancer]. In conclusion, we found that rs4954956 was associated with increased ovarian cancer risk, particularly for serous ovarian cancer. However, none of the six confirmed breast cancer susceptibility variants we tested was associated with ovarian cancer risk. Further work will be needed to identify the causal variant associated with rs4954956 or elucidate its function.

U2 - 10.1093/hmg/ddp138

DO - 10.1093/hmg/ddp138

M3 - Journal article

C2 - 19304784

SN - 0964-6906

VL - 18

SP - 2297

EP - 2304

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 12

ER -

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study

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