Association between diverticular disease and Ehlers-Danlos syndrome: a 13-year nationwide population-based cohort study

Julie Leganger; Marie-Louise Kulas Søborg; Laura Quitzau Mortensen; Rasmus Gregersen; Jacob Rosenberg; Jakob Burcharth

doi:10.1007/s00384-016-2650-2

Association between diverticular disease and Ehlers-Danlos syndrome: a 13-year nationwide population-based cohort study

Julie Leganger^*, Marie-Louise Kulas Søborg, Laura Quitzau Mortensen, Rasmus Gregersen, Jacob Rosenberg, Jakob Burcharth

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

9 Citationer (Scopus)

Abstract

Purpose: The aim of this study was to examine occurrence and consequences of diverticular disease in patients with Ehlers-Danlos syndrome (EDS) compared with a matched cohort.

Methods: This nationwide population-based cohort study was conducted using data from medical registers in Denmark from year 2000 to 2012. The EDS cohort was identified using the specific diagnosis code for EDS and was randomly matched in a ratio of 1:20 by sex and date of birth (±1 year) with persons from the Danish general population. The occurrence of diverticular disease and the clinical characteristics of the initial diverticular event were compared between the EDS cohort and the comparison cohort. The first admission with diverticulitis was identified, and severity of diverticulitis, treatment, colonoscopies, length of stay, and 30-day mortality were investigated.

Results: We identified 1336 patients with EDS and matched a control cohort of 26,720 patients. The occurrence of diverticular disease in the EDS cohort (2.0 %) and the comparison cohort (0.68 %) differed significantly (p < 0.001). At the first diverticular event, the majority of patients were women (85 % for EDS and 87 % for the comparison cohort). Mean age, localization, and type of contact did not differ significantly. Admission with diverticulitis (1.0 % for EDS and 0.34 % for the comparison cohort) differed significantly (p < 0.001). We found no significant difference in severity of diverticulitis, treatment, length of stay, or 30-day mortality between the EDS and the comparison cohorts.

Conclusions: Patients with EDS had an increased occurrence of overall diverticular events and admissions with diverticulitis compared with the general population.

Originalsprog	Engelsk
Tidsskrift	International Journal of Colorectal Disease
Vol/bind	31
Udgave nummer	12
Sider (fra-til)	1863-1867
Antal sider	5
ISSN	0179-1958
DOI	https://doi.org/10.1007/s00384-016-2650-2
Status	Udgivet - 2016

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10.1007/s00384-016-2650-2

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Association between diverticular disease and Ehlers-Danlos syndrome : a 13-year nationwide population-based cohort study. / Leganger, Julie; Søborg, Marie-Louise Kulas; Mortensen, Laura Quitzau et al.

I: International Journal of Colorectal Disease, Bind 31, Nr. 12, 2016, s. 1863-1867.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Association between diverticular disease and Ehlers-Danlos syndrome: a 13-year nationwide population-based cohort study",

abstract = "Purpose: The aim of this study was to examine occurrence and consequences of diverticular disease in patients with Ehlers-Danlos syndrome (EDS) compared with a matched cohort. Methods: This nationwide population-based cohort study was conducted using data from medical registers in Denmark from year 2000 to 2012. The EDS cohort was identified using the specific diagnosis code for EDS and was randomly matched in a ratio of 1:20 by sex and date of birth (±1 year) with persons from the Danish general population. The occurrence of diverticular disease and the clinical characteristics of the initial diverticular event were compared between the EDS cohort and the comparison cohort. The first admission with diverticulitis was identified, and severity of diverticulitis, treatment, colonoscopies, length of stay, and 30-day mortality were investigated. Results: We identified 1336 patients with EDS and matched a control cohort of 26,720 patients. The occurrence of diverticular disease in the EDS cohort (2.0 %) and the comparison cohort (0.68 %) differed significantly (p < 0.001). At the first diverticular event, the majority of patients were women (85 % for EDS and 87 % for the comparison cohort). Mean age, localization, and type of contact did not differ significantly. Admission with diverticulitis (1.0 % for EDS and 0.34 % for the comparison cohort) differed significantly (p < 0.001). We found no significant difference in severity of diverticulitis, treatment, length of stay, or 30-day mortality between the EDS and the comparison cohorts. Conclusions: Patients with EDS had an increased occurrence of overall diverticular events and admissions with diverticulitis compared with the general population.",

keywords = "Diverticular disease, Ehlers-Danlos syndrome, Mortality, Treatment",

author = "Julie Leganger and S{\o}borg, {Marie-Louise Kulas} and Mortensen, {Laura Quitzau} and Rasmus Gregersen and Jacob Rosenberg and Jakob Burcharth",

year = "2016",

doi = "10.1007/s00384-016-2650-2",

language = "English",

volume = "31",

pages = "1863--1867",

journal = "International Journal of Colorectal Disease",

issn = "0179-1958",

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TY - JOUR

T1 - Association between diverticular disease and Ehlers-Danlos syndrome

T2 - a 13-year nationwide population-based cohort study

AU - Leganger, Julie

AU - Søborg, Marie-Louise Kulas

AU - Mortensen, Laura Quitzau

AU - Gregersen, Rasmus

AU - Rosenberg, Jacob

AU - Burcharth, Jakob

PY - 2016

Y1 - 2016

N2 - Purpose: The aim of this study was to examine occurrence and consequences of diverticular disease in patients with Ehlers-Danlos syndrome (EDS) compared with a matched cohort. Methods: This nationwide population-based cohort study was conducted using data from medical registers in Denmark from year 2000 to 2012. The EDS cohort was identified using the specific diagnosis code for EDS and was randomly matched in a ratio of 1:20 by sex and date of birth (±1 year) with persons from the Danish general population. The occurrence of diverticular disease and the clinical characteristics of the initial diverticular event were compared between the EDS cohort and the comparison cohort. The first admission with diverticulitis was identified, and severity of diverticulitis, treatment, colonoscopies, length of stay, and 30-day mortality were investigated. Results: We identified 1336 patients with EDS and matched a control cohort of 26,720 patients. The occurrence of diverticular disease in the EDS cohort (2.0 %) and the comparison cohort (0.68 %) differed significantly (p < 0.001). At the first diverticular event, the majority of patients were women (85 % for EDS and 87 % for the comparison cohort). Mean age, localization, and type of contact did not differ significantly. Admission with diverticulitis (1.0 % for EDS and 0.34 % for the comparison cohort) differed significantly (p < 0.001). We found no significant difference in severity of diverticulitis, treatment, length of stay, or 30-day mortality between the EDS and the comparison cohorts. Conclusions: Patients with EDS had an increased occurrence of overall diverticular events and admissions with diverticulitis compared with the general population.

AB - Purpose: The aim of this study was to examine occurrence and consequences of diverticular disease in patients with Ehlers-Danlos syndrome (EDS) compared with a matched cohort. Methods: This nationwide population-based cohort study was conducted using data from medical registers in Denmark from year 2000 to 2012. The EDS cohort was identified using the specific diagnosis code for EDS and was randomly matched in a ratio of 1:20 by sex and date of birth (±1 year) with persons from the Danish general population. The occurrence of diverticular disease and the clinical characteristics of the initial diverticular event were compared between the EDS cohort and the comparison cohort. The first admission with diverticulitis was identified, and severity of diverticulitis, treatment, colonoscopies, length of stay, and 30-day mortality were investigated. Results: We identified 1336 patients with EDS and matched a control cohort of 26,720 patients. The occurrence of diverticular disease in the EDS cohort (2.0 %) and the comparison cohort (0.68 %) differed significantly (p < 0.001). At the first diverticular event, the majority of patients were women (85 % for EDS and 87 % for the comparison cohort). Mean age, localization, and type of contact did not differ significantly. Admission with diverticulitis (1.0 % for EDS and 0.34 % for the comparison cohort) differed significantly (p < 0.001). We found no significant difference in severity of diverticulitis, treatment, length of stay, or 30-day mortality between the EDS and the comparison cohorts. Conclusions: Patients with EDS had an increased occurrence of overall diverticular events and admissions with diverticulitis compared with the general population.

KW - Diverticular disease

KW - Ehlers-Danlos syndrome

KW - Mortality

KW - Treatment

U2 - 10.1007/s00384-016-2650-2

DO - 10.1007/s00384-016-2650-2

M3 - Journal article

C2 - 27604811

AN - SCOPUS:84986270370

SN - 0179-1958

VL - 31

SP - 1863

EP - 1867

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

IS - 12

ER -

Association between diverticular disease and Ehlers-Danlos syndrome: a 13-year nationwide population-based cohort study

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