Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Aline Jelenkovic; Yoshie Yokoyama; Reijo Sund; Kirsi H Pietiläinen; Yoon-Mi Hur; Gonneke Willemsen; Meike Bartels; Toos Cem van Beijsterveldt; Syuichi Ooki; Kimberly J Saudino; Maria A Stazi; Corrado Fagnani; Cristina D'Ippolito; Tracy L Nelson; Keith E Whitfield; Ariel Knafo-Noam; David Mankuta; Lior Abramson; Kauko Heikkilä; Tessa L Cutler; John L Hopper; Jane Wardle; Clare H Llewellyn; Abigail Fisher; Robin P Corley; Brooke M Huibregtse; Catherine A Derom; Robert F Vlietinck; Ruth Jf Loos; Morten Bjerregaard-Andersen; Henning Beck-Nielsen; Morten Sodemann; Adam D Tarnoki; David L Tarnoki; S Alexandra Burt; Kelly L Klump; Juan R Ordoñana; Juan F Sánchez-Romera; Lucia Colodro-Conde; Lise Dubois; Michel Boivin; Mara Brendgen; Ginette Dionne; Frank Vitaro; Jennifer R Harris; Ingunn Brandt; Thomas Sevenius Nilsen; Jeffrey M Craig; Richard Saffery; Finn Rasmussen; Per Tynelius; Gombojav Bayasgalan; Danshiitsoodol Narandalai; Claire Ma Haworth; Robert Plomin; Fuling Ji; Feng Ning; Zengchang Pang; Esther Rebato; Robert F Krueger; Matt McGue; Shandell Pahlen; Dorret I Boomsma; Thorkild Ia Sørensen; Jaakko Kaprio; Karri Silventoinen

doi:10.1093/ije/dyx031

Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietiläinen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, Toos Cem van Beijsterveldt, Syuichi Ooki, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Kauko Heikkilä, Tessa L CutlerJohn L Hopper, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth Jf Loos, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, S Alexandra Burt, Kelly L Klump, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire Ma Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Robert F Krueger, Matt McGue, Shandell Pahlen, Dorret I Boomsma, Thorkild Ia Sørensen, Jaakko Kaprio, Karri Silventoinen

Institut for Folkesundhedsvidenskab

12 Citationer (Scopus)

42 Downloads (Pure)

Abstract

Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m² higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m² per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

Originalsprog	Engelsk
Tidsskrift	International Journal of Epidemiology
Vol/bind	46
Udgave nummer	5
Sider (fra-til)	1488-1498
Antal sider	11
ISSN	0300-5771
DOI	https://doi.org/10.1093/ije/dyx031
Status	Udgivet - okt. 2017

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10.1093/ije/dyx031Licens: CC BY

Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project Forlagets udgivne version, 404 KBLicens: CC BY

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Jelenkovic, A., Yokoyama, Y., Sund, R., Pietiläinen, K. H., Hur, Y-M., Willemsen, G., Bartels, M., van Beijsterveldt, T. C., Ooki, S., Saudino, K. J., Stazi, M. A., Fagnani, C., D'Ippolito, C., Nelson, T. L., Whitfield, K. E., Knafo-Noam, A., Mankuta, D., Abramson, L., Heikkilä, K., ... Silventoinen, K. (2017). Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. International Journal of Epidemiology, 46(5), 1488-1498. https://doi.org/10.1093/ije/dyx031

Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. / Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo et al.

I: International Journal of Epidemiology, Bind 46, Nr. 5, 10.2017, s. 1488-1498.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jelenkovic, A, Yokoyama, Y, Sund, R, Pietiläinen, KH, Hur, Y-M, Willemsen, G, Bartels, M, van Beijsterveldt, TC, Ooki, S, Saudino, KJ, Stazi, MA, Fagnani, C, D'Ippolito, C, Nelson, TL, Whitfield, KE, Knafo-Noam, A, Mankuta, D, Abramson, L, Heikkilä, K, Cutler, TL, Hopper, JL, Wardle, J, Llewellyn, CH, Fisher, A, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJ, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Burt, SA, Klump, KL, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Harris, JR, Brandt, I, Nilsen, TS, Craig, JM, Saffery, R, Rasmussen, F, Tynelius, P, Bayasgalan, G, Narandalai, D, Haworth, CM, Plomin, R, Ji, F, Ning, F, Pang, Z, Rebato, E, Krueger, RF, McGue, M, Pahlen, S, Boomsma, DI, Sørensen, TI, Kaprio, J & Silventoinen, K 2017, 'Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project', International Journal of Epidemiology, bind 46, nr. 5, s. 1488-1498. https://doi.org/10.1093/ije/dyx031

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abstract = "Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.",

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year = "2017",

month = oct,

doi = "10.1093/ije/dyx031",

language = "English",

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pages = "1488--1498",

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TY - JOUR

T1 - Association between birthweight and later body mass index

T2 - an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

AU - Jelenkovic, Aline

AU - Yokoyama, Yoshie

AU - Sund, Reijo

AU - Pietiläinen, Kirsi H

AU - Hur, Yoon-Mi

AU - Willemsen, Gonneke

AU - Bartels, Meike

AU - van Beijsterveldt, Toos Cem

AU - Ooki, Syuichi

AU - Saudino, Kimberly J

AU - Stazi, Maria A

AU - Fagnani, Corrado

AU - D'Ippolito, Cristina

AU - Nelson, Tracy L

AU - Whitfield, Keith E

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Heikkilä, Kauko

AU - Cutler, Tessa L

AU - Hopper, John L

AU - Wardle, Jane

AU - Llewellyn, Clare H

AU - Fisher, Abigail

AU - Corley, Robin P

AU - Huibregtse, Brooke M

AU - Derom, Catherine A

AU - Vlietinck, Robert F

AU - Loos, Ruth Jf

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Tarnoki, Adam D

AU - Tarnoki, David L

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Ordoñana, Juan R

AU - Sánchez-Romera, Juan F

AU - Colodro-Conde, Lucia

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Harris, Jennifer R

AU - Brandt, Ingunn

AU - Nilsen, Thomas Sevenius

AU - Craig, Jeffrey M

AU - Saffery, Richard

AU - Rasmussen, Finn

AU - Tynelius, Per

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Haworth, Claire Ma

AU - Plomin, Robert

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Rebato, Esther

AU - Krueger, Robert F

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Boomsma, Dorret I

AU - Sørensen, Thorkild Ia

AU - Kaprio, Jaakko

AU - Silventoinen, Karri

PY - 2017/10

Y1 - 2017/10

N2 - Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

AB - Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

KW - Journal Article

U2 - 10.1093/ije/dyx031

DO - 10.1093/ije/dyx031

M3 - Journal article

C2 - 28369451

SN - 0300-5771

VL - 46

SP - 1488

EP - 1498

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 5

ER -

Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Abstract

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