Association analyses of depression and genes in the hypothalamus-pituitary-adrenal axis

TY - JOUR

T1 - Association analyses of depression and genes in the hypothalamus-pituitary-adrenal axis

AU - Buttenschøn, Henrietta Nørmølle

AU - Krogh, Jesper

AU - Nielsen, Marit Nyholm

AU - Kaerlev, Linda

AU - Nordentoft, Merete

AU - Mors, Ole

PY - 2017/2/1

Y1 - 2017/2/1

N2 - OBJECTIVE: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in depression. The aim was to investigate the potential association between depression and seven genes regulating or interfering with the HPA axis, including the gene encoding angiotensin converting enzyme (ACE).METHODS: In total, 78 single nucleotide polymorphisms (SNPs) and one insertion/deletion polymorphism were genotyped. The study included 408 individuals with depression and 289 controls. In a subset of cases, the interaction between genetic variants and stressful life events (SLEs) was investigated.RESULTS: After quality control, 68 genetic variants were left for analyses. Four of nine variants within ACE were nominally associated with depression and a gene-wise association was likewise observed. However, none of the SNPs located within AVP, CRH, CRHR1, CRHR2, FKBP5 or NC3C1 were associated with depression. One nominally significant interaction, most likely due to chance, was identified.CONCLUSION: The results indicate that ACE could be a potential candidate gene for depression.

AB - OBJECTIVE: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in depression. The aim was to investigate the potential association between depression and seven genes regulating or interfering with the HPA axis, including the gene encoding angiotensin converting enzyme (ACE).METHODS: In total, 78 single nucleotide polymorphisms (SNPs) and one insertion/deletion polymorphism were genotyped. The study included 408 individuals with depression and 289 controls. In a subset of cases, the interaction between genetic variants and stressful life events (SLEs) was investigated.RESULTS: After quality control, 68 genetic variants were left for analyses. Four of nine variants within ACE were nominally associated with depression and a gene-wise association was likewise observed. However, none of the SNPs located within AVP, CRH, CRHR1, CRHR2, FKBP5 or NC3C1 were associated with depression. One nominally significant interaction, most likely due to chance, was identified.CONCLUSION: The results indicate that ACE could be a potential candidate gene for depression.

KW - Depressive Disorder/genetics

KW - Female

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Hypothalamo-Hypophyseal System/enzymology

KW - Male

KW - Peptidyl-Dipeptidase A/genetics

KW - Pituitary-Adrenal System/enzymology

KW - Polymorphism, Single Nucleotide

U2 - 10.1017/neu.2016.26

DO - 10.1017/neu.2016.26

M3 - Journal article

C2 - 27264499

SN - 0924-2708

VL - 29

SP - 59

EP - 64

JO - Acta Neuropsychiatrica

JF - Acta Neuropsychiatrica

IS - 1

ER -