TY - JOUR
T1 - Assisted reproductive technology (ART) treatment in women with schizophrenia or related psychotic disorder
T2 - a national cohort study
AU - Ebdrup, Ninna H
AU - Assens, Maria
AU - Hougaard, Charlotte O
AU - Pinborg, Anja
AU - Pedersen, Ida Hageman
AU - Schmidt, Lone
N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
PY - 2014/6
Y1 - 2014/6
N2 - Objectives To determine the prevalence rate of women with a diagnosis of schizophrenia or related psychotic disorder in assisted reproductive technology (ART) treatment and to study these women's fertility treatment outcome in comparison to women with no psychotic disorders. Study design We used a national register-based cohort of 42,915 Danish women in ART treatment from 1.1.1994 to 30.9.2009. All women with a diagnosis of schizophrenia or related psychotic disorders before, during or after their ART treatment were identified by individual-level linkage of nationwide registers of ART treatment, psychiatric admission, birth and socio-demographic status. The comparison group (N = 42,671) consisted of all women in the study cohort never diagnosed with psychotic disorders. Conventional descriptive methods were used for the statistical analyses. Results Two hundred and forty-four (0.6%) women in the study cohort received a diagnosis of psychotic disorder before (N = 135-55.3%), during (N = 7-2.9%) or after (N = 102-41.8%) ART treatment. The mean time from last diagnosis of psychotic disorder to their first ART treatment in the 135 women with a psychiatric diagnosis prior to their first ART treatment was 7.1 ± 5.6 years (25-75% percentile: ±2.8-10.4 years). The most frequent diagnoses were acute and transient psychotic disorder. Women with a diagnosis of schizophrenia or related psychotic disorder before their first ART treatment had a lower ART treatment success rate as significantly fewer women obtained a live birth (40.0% vs. 51.9%, P < 0.01). However, we found no statistical differences in perinatal outcomes for the children born by women in the study population and comparison group. Conclusions The prevalence of women with a psychotic diagnosis in fertility treatment is lower than the prevalence in the general population. Women with a psychotic disorder prior to ART treatment have a lower fertility treatment success rate compared to women without psychotic disorder. Women with a psychotic disorder achieving delivery show similar obstetric outcomes to women with no psychotic disorder.
AB - Objectives To determine the prevalence rate of women with a diagnosis of schizophrenia or related psychotic disorder in assisted reproductive technology (ART) treatment and to study these women's fertility treatment outcome in comparison to women with no psychotic disorders. Study design We used a national register-based cohort of 42,915 Danish women in ART treatment from 1.1.1994 to 30.9.2009. All women with a diagnosis of schizophrenia or related psychotic disorders before, during or after their ART treatment were identified by individual-level linkage of nationwide registers of ART treatment, psychiatric admission, birth and socio-demographic status. The comparison group (N = 42,671) consisted of all women in the study cohort never diagnosed with psychotic disorders. Conventional descriptive methods were used for the statistical analyses. Results Two hundred and forty-four (0.6%) women in the study cohort received a diagnosis of psychotic disorder before (N = 135-55.3%), during (N = 7-2.9%) or after (N = 102-41.8%) ART treatment. The mean time from last diagnosis of psychotic disorder to their first ART treatment in the 135 women with a psychiatric diagnosis prior to their first ART treatment was 7.1 ± 5.6 years (25-75% percentile: ±2.8-10.4 years). The most frequent diagnoses were acute and transient psychotic disorder. Women with a diagnosis of schizophrenia or related psychotic disorder before their first ART treatment had a lower ART treatment success rate as significantly fewer women obtained a live birth (40.0% vs. 51.9%, P < 0.01). However, we found no statistical differences in perinatal outcomes for the children born by women in the study population and comparison group. Conclusions The prevalence of women with a psychotic diagnosis in fertility treatment is lower than the prevalence in the general population. Women with a psychotic disorder prior to ART treatment have a lower fertility treatment success rate compared to women without psychotic disorder. Women with a psychotic disorder achieving delivery show similar obstetric outcomes to women with no psychotic disorder.
U2 - 10.1016/j.ejogrb.2014.03.013
DO - 10.1016/j.ejogrb.2014.03.013
M3 - Journal article
C2 - 24721442
SN - 0301-2115
VL - 177
SP - 115
EP - 120
JO - European Journal of Obstetrics & Gynecology and Reproductive Biology
JF - European Journal of Obstetrics & Gynecology and Reproductive Biology
ER -