Assay validation and diagnostic applications of major acute-phase protein testing in companion animals

TY - JOUR

T1 - Assay validation and diagnostic applications of major acute-phase protein testing in companion animals

AU - Kjelgaard-Hansen, Mads

AU - Jacobsen, Stine

PY - 2011/3

Y1 - 2011/3

N2 - The use of major acute-phase proteins (APPs) for assessment of health and disease in companion animals has increased within the last decade because of increased knowledge in the field and increased access to appropriate assay systems for detection of relevant APPs, which are highly species specific. Despite evidence being restricted almost solely to proven excellent overlap performance of these markers in detecting inflammatory activity, clinically relevant studies at higher evidence levels do exist. The available body of literature shows a clear, but seemingly untapped, potential for more extended routine clinical use of major APP testing in companion animal medicine.

AB - The use of major acute-phase proteins (APPs) for assessment of health and disease in companion animals has increased within the last decade because of increased knowledge in the field and increased access to appropriate assay systems for detection of relevant APPs, which are highly species specific. Despite evidence being restricted almost solely to proven excellent overlap performance of these markers in detecting inflammatory activity, clinically relevant studies at higher evidence levels do exist. The available body of literature shows a clear, but seemingly untapped, potential for more extended routine clinical use of major APP testing in companion animal medicine.

U2 - 10.1016/j.cll.2010.10.002

DO - 10.1016/j.cll.2010.10.002

M3 - Journal article

C2 - 21295722

SN - 0272-2712

VL - 31

SP - 51

EP - 70

JO - Clinics in Laboratory Medicine

JF - Clinics in Laboratory Medicine

IS - 1

ER -