Archaeal promoter architecture and mechanism of gene activation

Nan Peng; Xiang Ao; Yun Xiang Liang; Qunxin She

doi:10.1042/bst0390099

Archaeal promoter architecture and mechanism of gene activation

Nan Peng, Xiang Ao, Yun Xiang Liang, Qunxin She

Functional genomics

17 Citationer (Scopus)

Abstract

Sulfolobus solfataricus and Sulfolobus islandicus contain several genes exhibiting D-arabinose-inducible expression and these systems are ideal for studying mechanisms of archaeal gene expression. At sequence level, only two highly conserved cis elements are present on the promoters: a regulatory element named ara box directing arabinose-inducible expression and the basal promoter element TATA, serving as the binding site for the TATA-binding protein. Strikingly, these promoters possess a modular structure that allows an essentially inactive basal promoter to be strongly activated. The invoked mechanisms include TFB (transcription factor B) recruitment by the ara-box-binding factor to activate gene expression and modulation of TFB recruitment efficiency to yield differential gene expression.

Originalsprog	Engelsk
Tidsskrift	Biochemical Society Transactions
Vol/bind	39
Udgave nummer	1
Sider (fra-til)	99-103
Antal sider	5
ISSN	0300-5127
DOI	https://doi.org/10.1042/bst0390099
Status	Udgivet - feb. 2011

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10.1042/bst0390099

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AU - Liang, Yun Xiang

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N2 - Sulfolobus solfataricus and Sulfolobus islandicus contain several genes exhibiting D-arabinose-inducible expression and these systems are ideal for studying mechanisms of archaeal gene expression. At sequence level, only two highly conserved cis elements are present on the promoters: a regulatory element named ara box directing arabinose-inducible expression and the basal promoter element TATA, serving as the binding site for the TATA-binding protein. Strikingly, these promoters possess a modular structure that allows an essentially inactive basal promoter to be strongly activated. The invoked mechanisms include TFB (transcription factor B) recruitment by the ara-box-binding factor to activate gene expression and modulation of TFB recruitment efficiency to yield differential gene expression.

AB - Sulfolobus solfataricus and Sulfolobus islandicus contain several genes exhibiting D-arabinose-inducible expression and these systems are ideal for studying mechanisms of archaeal gene expression. At sequence level, only two highly conserved cis elements are present on the promoters: a regulatory element named ara box directing arabinose-inducible expression and the basal promoter element TATA, serving as the binding site for the TATA-binding protein. Strikingly, these promoters possess a modular structure that allows an essentially inactive basal promoter to be strongly activated. The invoked mechanisms include TFB (transcription factor B) recruitment by the ara-box-binding factor to activate gene expression and modulation of TFB recruitment efficiency to yield differential gene expression.

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M3 - Journal article

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JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

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Archaeal promoter architecture and mechanism of gene activation

Abstract

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