Applied mediation analyses: a review and tutorial

Theis Lange; Kim Wadt Hansen; Rikke Sørensen; Søren Galatius

doi:10.4178/epih.e2017035

Applied mediation analyses: a review and tutorial

Theis Lange, Kim Wadt Hansen, Rikke Sørensen, Søren Galatius

Biostatistisk afdeling

31 Citationer (Scopus)

177 Downloads (Pure)

Abstract

In recent years, mediation analysis has emerged as a powerful tool to disentangle causal pathways from an exposure/treatment to clinically relevant outcomes. Mediation analysis has been applied in scientific fields as diverse as labour market relations and randomized clinical trials of heart disease treatments. In parallel to these applications, the underlying mathematical theory and computer tools have been refined. This combined review and tutorial will introduce the reader to modern mediation analysis including: the mathematical framework; required assumptions; and software implementation in the R package medflex. All results are illustrated using a recent study on the causal pathways stemming from the early invasive treatment of acute coronary syndrome, for which the rich Danish population registers allow us to follow patients' medication use and more after being discharged from hospital.

Originalsprog	Engelsk
Artikelnummer	e2017035
Tidsskrift	Epidemiology and health
Vol/bind	39
Sider (fra-til)	1-13
Antal sider	13
DOI	https://doi.org/10.4178/epih.e2017035
Status	Udgivet - 2021

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10.4178/epih.e2017035Licens: CC BY

Applied mediation analyses a review and tutorialForlagets udgivne version, 555 KBLicens: CC BY

Citationsformater

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AU - Hansen, Kim Wadt

AU - Sørensen, Rikke

AU - Galatius, Søren

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Y1 - 2021

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AB - In recent years, mediation analysis has emerged as a powerful tool to disentangle causal pathways from an exposure/treatment to clinically relevant outcomes. Mediation analysis has been applied in scientific fields as diverse as labour market relations and randomized clinical trials of heart disease treatments. In parallel to these applications, the underlying mathematical theory and computer tools have been refined. This combined review and tutorial will introduce the reader to modern mediation analysis including: the mathematical framework; required assumptions; and software implementation in the R package medflex. All results are illustrated using a recent study on the causal pathways stemming from the early invasive treatment of acute coronary syndrome, for which the rich Danish population registers allow us to follow patients' medication use and more after being discharged from hospital.

KW - Journal Article

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Applied mediation analyses: a review and tutorial

Abstract

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