Applications of Systems Genetics and Biology for Obesity Using Pig Models

TY - CHAP

T1 - Applications of Systems Genetics and Biology for Obesity Using Pig Models

AU - Kogelman, Lisette

AU - Kadarmideen, Haja N.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - In many biomedical research areas, animals have been used as a model to increase the understanding of molecular mechanisms involved in human diseases. One of those areas is human obesity, where porcine models are increasingly used. The pig shows genetic and physiological features that are very similar to humans and have shown to be an excellent model for human obesity. Using pig populations, many genetic studies have been performed to unravel the genetic architecture of human obesity. Most of them are pinpointing toward single genes, but more and more studies focus on a systems genetics approach, a branch of systems biology. In this chapter, we will describe the state of the art of genetic studies on human obesity, using pig populations. We will describe the features of using the pig as a model for human obesity and briefly discuss the genetics of obesity, and we will focus on systems genetic research performed using pigs with their contribution to human obesity research.

AB - In many biomedical research areas, animals have been used as a model to increase the understanding of molecular mechanisms involved in human diseases. One of those areas is human obesity, where porcine models are increasingly used. The pig shows genetic and physiological features that are very similar to humans and have shown to be an excellent model for human obesity. Using pig populations, many genetic studies have been performed to unravel the genetic architecture of human obesity. Most of them are pinpointing toward single genes, but more and more studies focus on a systems genetics approach, a branch of systems biology. In this chapter, we will describe the state of the art of genetic studies on human obesity, using pig populations. We will describe the features of using the pig as a model for human obesity and briefly discuss the genetics of obesity, and we will focus on systems genetic research performed using pigs with their contribution to human obesity research.

UR - https://curis.ku.dk/admin/files/169060858/SysBioBookChp_2_v1.pdf

U2 - 10.1007/978-3-319-43335-6_2

DO - 10.1007/978-3-319-43335-6_2

M3 - Book chapter

SN - 9783319433332

VL - 1

SP - 25

EP - 42

BT - Systems Biology in Animal Production and Health

A2 - Kadarmideen, Haja N.

PB - Springer

CY - Cham

ER -