Application of Temperature-Correlated Mobility Theory for Optimizing the MEKC Separation of the Main Lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction

Jingyi Liu; Nickolaj J. Petersen; Kaifai Lee; Steen Honoré Hansen; Lixing Lao; Chowing Sze; Yanbo Zhang

doi:10.1002/elps.201400007

Application of Temperature-Correlated Mobility Theory for Optimizing the MEKC Separation of the Main Lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction

Jingyi Liu, Nickolaj J. Petersen, Kaifai Lee, Steen Honoré Hansen, Lixing Lao, Chowing Sze, Yanbo Zhang

2 Citationer (Scopus)

Abstract

The present work shows the application of the temperature-correlated mobility theory for the optimization of the separation and peak alignment of the main lignans from water extracts of traditional Chinese medicine Schisandra Chinensis Fructus as well as its prescription Yuye Decoction (Jade Fluid Decoction; YYD). This is the first application of this theory for MEKC separations, and the data presentation allows a much easier peak tracking and thereby identification of the analytes. Most interestingly, the data obtained and presented in the mobility scale at 298 K, show that Schisantherin A, which is easily mistaken as one of the analytes using traditional time scale, was actually not detected in Schisandra Chinensis Fructus and Yuye Decoction (Jade Fluid Decoction) water extracts. This proves the value of the temperature-correlated mobility scale for method optimization of complex samples. Thus, in the temperature-correlated mobility scale, the optimization of the system conditions for the MEKC separations can easily be achieved by correcting for viscosity changes. Also, the influence of the operating temperature can be monitored in a more distinct way.

Originalsprog	Engelsk
Tidsskrift	Electrophoresis
Vol/bind	35
Udgave nummer	20
Sider (fra-til)	2907-14
Antal sider	8
ISSN	0173-0835
DOI	https://doi.org/10.1002/elps.201400007
Status	Udgivet - 1 okt. 2014

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10.1002/elps.201400007

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Application of Temperature-Correlated Mobility Theory for Optimizing the MEKC Separation of the Main Lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction. / Liu, Jingyi; Petersen, Nickolaj J.; Lee, Kaifai et al.

I: Electrophoresis, Bind 35, Nr. 20, 01.10.2014, s. 2907-14.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "The present work shows the application of the temperature-correlated mobility theory for the optimization of the separation and peak alignment of the main lignans from water extracts of traditional Chinese medicine Schisandra Chinensis Fructus as well as its prescription Yuye Decoction (Jade Fluid Decoction; YYD). This is the first application of this theory for MEKC separations, and the data presentation allows a much easier peak tracking and thereby identification of the analytes. Most interestingly, the data obtained and presented in the mobility scale at 298 K, show that Schisantherin A, which is easily mistaken as one of the analytes using traditional time scale, was actually not detected in Schisandra Chinensis Fructus and Yuye Decoction (Jade Fluid Decoction) water extracts. This proves the value of the temperature-correlated mobility scale for method optimization of complex samples. Thus, in the temperature-correlated mobility scale, the optimization of the system conditions for the MEKC separations can easily be achieved by correcting for viscosity changes. Also, the influence of the operating temperature can be monitored in a more distinct way.",

author = "Jingyi Liu and Petersen, {Nickolaj J.} and Kaifai Lee and Hansen, {Steen Honor{\'e}} and Lixing Lao and Chowing Sze and Yanbo Zhang",

year = "2014",

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T1 - Application of Temperature-Correlated Mobility Theory for Optimizing the MEKC Separation of the Main Lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction

AU - Liu, Jingyi

AU - Petersen, Nickolaj J.

AU - Lee, Kaifai

AU - Hansen, Steen Honoré

AU - Lao, Lixing

AU - Sze, Chowing

AU - Zhang, Yanbo

PY - 2014/10/1

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N2 - The present work shows the application of the temperature-correlated mobility theory for the optimization of the separation and peak alignment of the main lignans from water extracts of traditional Chinese medicine Schisandra Chinensis Fructus as well as its prescription Yuye Decoction (Jade Fluid Decoction; YYD). This is the first application of this theory for MEKC separations, and the data presentation allows a much easier peak tracking and thereby identification of the analytes. Most interestingly, the data obtained and presented in the mobility scale at 298 K, show that Schisantherin A, which is easily mistaken as one of the analytes using traditional time scale, was actually not detected in Schisandra Chinensis Fructus and Yuye Decoction (Jade Fluid Decoction) water extracts. This proves the value of the temperature-correlated mobility scale for method optimization of complex samples. Thus, in the temperature-correlated mobility scale, the optimization of the system conditions for the MEKC separations can easily be achieved by correcting for viscosity changes. Also, the influence of the operating temperature can be monitored in a more distinct way.

AB - The present work shows the application of the temperature-correlated mobility theory for the optimization of the separation and peak alignment of the main lignans from water extracts of traditional Chinese medicine Schisandra Chinensis Fructus as well as its prescription Yuye Decoction (Jade Fluid Decoction; YYD). This is the first application of this theory for MEKC separations, and the data presentation allows a much easier peak tracking and thereby identification of the analytes. Most interestingly, the data obtained and presented in the mobility scale at 298 K, show that Schisantherin A, which is easily mistaken as one of the analytes using traditional time scale, was actually not detected in Schisandra Chinensis Fructus and Yuye Decoction (Jade Fluid Decoction) water extracts. This proves the value of the temperature-correlated mobility scale for method optimization of complex samples. Thus, in the temperature-correlated mobility scale, the optimization of the system conditions for the MEKC separations can easily be achieved by correcting for viscosity changes. Also, the influence of the operating temperature can be monitored in a more distinct way.

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ER -

Application of Temperature-Correlated Mobility Theory for Optimizing the MEKC Separation of the Main Lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction

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