Apoptose ved kronisk inflammatorisk tarmsygdom. Betydning for patogenese og behandling

Jakob Benedict Seidelin; Ole Haagen Nielsen

Apoptose ved kronisk inflammatorisk tarmsygdom. Betydning for patogenese og behandling

Jakob Benedict Seidelin, Ole Haagen Nielsen

Institut for Klinisk Medicin

6 Citationer (Scopus)

Abstract

Inflammatory bowel disease (IBD) is characterized by the increased survival of lamina propria leucocytes and ulcerations and an increased epithelial leakiness that compromise the barrier function of the epithelial lining. Deregulated apoptosis seems to be a major cause of the impaired barrier function and of leucocyte survival. This review focuses on the regulation of epithelial and leucocyte apoptosis in the IBD colon. Furthermore, the implications for present and future therapeutic strategies are discussed.

Bidragets oversatte titel	Apoptosis in chronic inflammatory bowel disease. The importance for pathogenesis and treatment
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	165
Udgave nummer	8
Sider (fra-til)	790-2
Antal sider	3
ISSN	0041-5782
Status	Udgivet - 17 feb. 2003

Emneord

Apoptosis
Colitis, Ulcerative
Crohn Disease
Epithelial Cells
Humans
Leukocytes

Citationsformater

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abstract = "Inflammatory bowel disease (IBD) is characterized by the increased survival of lamina propria leucocytes and ulcerations and an increased epithelial leakiness that compromise the barrier function of the epithelial lining. Deregulated apoptosis seems to be a major cause of the impaired barrier function and of leucocyte survival. This review focuses on the regulation of epithelial and leucocyte apoptosis in the IBD colon. Furthermore, the implications for present and future therapeutic strategies are discussed.",

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AU - Seidelin, Jakob Benedict

AU - Nielsen, Ole Haagen

PY - 2003/2/17

Y1 - 2003/2/17

N2 - Inflammatory bowel disease (IBD) is characterized by the increased survival of lamina propria leucocytes and ulcerations and an increased epithelial leakiness that compromise the barrier function of the epithelial lining. Deregulated apoptosis seems to be a major cause of the impaired barrier function and of leucocyte survival. This review focuses on the regulation of epithelial and leucocyte apoptosis in the IBD colon. Furthermore, the implications for present and future therapeutic strategies are discussed.

AB - Inflammatory bowel disease (IBD) is characterized by the increased survival of lamina propria leucocytes and ulcerations and an increased epithelial leakiness that compromise the barrier function of the epithelial lining. Deregulated apoptosis seems to be a major cause of the impaired barrier function and of leucocyte survival. This review focuses on the regulation of epithelial and leucocyte apoptosis in the IBD colon. Furthermore, the implications for present and future therapeutic strategies are discussed.

KW - Apoptosis

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Epithelial Cells

KW - Humans

KW - Leukocytes

KW - English Abstract

KW - Journal Article

M3 - Tidsskriftartikel

C2 - 12625119

SN - 0041-5782

VL - 165

SP - 790

EP - 792

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 8

ER -

Apoptose ved kronisk inflammatorisk tarmsygdom. Betydning for patogenese og behandling

Abstract

Emneord

Fingeraftryk

Citationsformater